Discovery, Synthesis and Mechanism of Marine Drugs for Treating Cancer

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Synthesis and Medicinal Chemistry of Marine Natural Products".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 585

Special Issue Editors


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Guest Editor
CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Center for Ocean Mega-Science, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China
Interests: drug discovery and development; medicinal chemistry; synthesis; structural modification; anti-tumor activity

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Guest Editor
Department of Pharmacy, Qingdao University of Science and Technology, Qingdao 266041, China
Interests: mechanism; cancer; marine polysaccharides; drug delivery

Special Issue Information

Dear Colleagues,

Cancer is a significant health problem globally.  Marine biology, as one of the richest sources of natural products, with different types of skeletons, offers numerous opportunities for the development of new anti-tumor drugs.  Recently, a number of novel anti-tumor drugs have been obtained from marine sources or prepared by synthesis/semi-synthesis from bioactive marine products. The synthesis and structural modification of lead compounds further enhance opportunities for the discovery of anti-tumor drugs.

Therefore, this Special Issue will explore the synthesis and structural modification of potent active marine drugs in vitro and in vivo. Studies related to the discovery of marine anticancer drugs, as well as the target and mechanism of action, are welcome.

Dr. Lijun Wang
Dr. Chuanlong Guo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • anti-tumor drugs
  • total synthesis
  • structural optimization
  • modification
  • mechanism

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Published Papers (1 paper)

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Research

20 pages, 3069 KiB  
Article
Cynthichlorine Extracted from Ascidian Cynthia savignyi from Djibouti: Optimization of Extraction, In Vitro Anticancer Profiling, and In Silico Approach
by Fatouma Mohamed Abdoul-Latif, Houda Mohamed, Ibrahim Houmed Aboubaker, Omaima Saoudi, Ayoub Ainane, Ali Merito Ali, Stefano Cacciatore, Luiz Fernando Zerbini, Abdelmjid Abourriche and Tarik Ainane
Mar. Drugs 2025, 23(4), 172; https://doi.org/10.3390/md23040172 - 16 Apr 2025
Viewed by 268
Abstract
This work focuses on the extraction of cynthichlorine from the ascidian Cynthia savignyi, a molecule that has potential promise as an anticancer agent. The main objective was to optimize the extraction conditions and evaluate the cytotoxic activity of cynthichlorine in tumor cell [...] Read more.
This work focuses on the extraction of cynthichlorine from the ascidian Cynthia savignyi, a molecule that has potential promise as an anticancer agent. The main objective was to optimize the extraction conditions and evaluate the cytotoxic activity of cynthichlorine in tumor cell lines. Two extraction methods, maceration and Soxhlet extraction, were compared, with maceration showing a significantly higher yield (2.2 ± 0.2%) compared to Soxhlet extraction (1.0 ± 0.2%). An optimization of the factors influencing the extraction was performed using the Box–Behnken method, showing that the extraction temperature and time have a negative impact on the yield, with the optimal conditions of temperature being below 25 °C and those of extraction time being below 12 h. Cytotoxic activity assessment revealed the marked inhibition of cell growth in all tested lines (U87-MG, U2OS, NCI-N87, HCT116, and A2780), with IC50 values ranging from 0.162 µg/mL in U87-MG to 0.576 µg/mL in NCI-N87. Finally, computational analysis showed that cynthichlorine exhibits high electronic stability and notable affinity for some biological targets, including NM23-H2, suggesting its potential as a targeted therapy in cancer treatment. These results pave the way for future studies on the therapeutic use of cynthichlorine. Full article
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