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Natural Products from Soft Corals and Their Associated Microbes

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Structural Studies on Marine Natural Products".

Deadline for manuscript submissions: 30 September 2026 | Viewed by 2368

Special Issue Editor


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Guest Editor
Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, China
Interests: marine organism; marine natural products; chemical biology; drug discovery

Special Issue Information

Dear Colleagues,

Soft corals have attracted significant attention due to their rich structural diversity and remarkable bioactive compounds. Over the years, a multitude of secondary metabolites—such as terpenoids, steroids, and quinones—have been discovered in these organisms and their associated microbes, demonstrating a wide range of biological activities including antimicrobial, anti-inflammatory, anticancer, and antiviral effects. This Special Issue focuses on novel structures and bioactive compounds derived from marine soft corals and their symbiotic microorganisms, offering researchers the opportunity to publish original work on topics including novel compound discovery, biosynthesis pathways, synthetic derivatives based on marine natural products, bioactivity evaluation, chemical ecology, and pharmacological mechanisms.

Dr. Ming-Zhi Su
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • soft corals
  • soft coral-associated microbes
  • marine natural products
  • synthetic derivatives based on marine natural products
  • biosynthesis pathways
  • bioactivity
  • chemical ecology
  • pharmacological mechanism

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Published Papers (2 papers)

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Research

17 pages, 3718 KB  
Article
Ghardaqenoids A–F: Six New Diterpenoids from the South China Sea Soft Coral Heteroxenia ghardaqensis with Lipid-Lowering Activity via the Activation of the AMPK Signaling Pathway
by Yue Zhang, Xin Han, Juan Wu, Shan Liu, Hongwei Zhang, Lili Zhao and Guoqiang Li
Mar. Drugs 2026, 24(1), 30; https://doi.org/10.3390/md24010030 - 8 Jan 2026
Viewed by 999
Abstract
Six new diterpenoids, including two verticillane ghardaqenoids A–B (12) and four dolabellane ghardaqenoids C–F (36), were isolated from the soft coral Heteroxenia ghardaqensis collected in the South China Sea. The structures of ghardaqenoids A, D, [...] Read more.
Six new diterpenoids, including two verticillane ghardaqenoids A–B (12) and four dolabellane ghardaqenoids C–F (36), were isolated from the soft coral Heteroxenia ghardaqensis collected in the South China Sea. The structures of ghardaqenoids A, D, and E (1, 4, 5) were determined by X-ray diffraction. Ghardaqenoids B, C, and F (2, 3, 6) were identified on the basis of NMR data, DP4+, and ECD spectral data. In particular, compound 6 exhibited strong in vitro lipid-lowering activity in free fatty acid (FFA)-induced HepG2 cells and liver organoids. Further mechanistic studies revealed that compound 6 regulated AMPK-related proteins and genes, thereby inhibiting the accumulation of triglycerides (TG) and total cholesterol (TC). These findings suggested that pharmacological AMPK activation serves as a promising role in lipid-lowering therapeutic strategies. Full article
(This article belongs to the Special Issue Natural Products from Soft Corals and Their Associated Microbes)
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17 pages, 11042 KB  
Article
Novel PPAR-γ Agonist from the Soft Coral Sarcophyton crassocaule: Modulating Glucose Uptake and Lipid Droplet Formation
by Jian-Ang Zeng, Min Sun, Yi Qi, Song-Wei Li, Li-Ting Zhang, Si-Min Pan, Yue-Wei Guo, Ming-Zhi Su and Hui Luo
Mar. Drugs 2025, 23(12), 450; https://doi.org/10.3390/md23120450 - 24 Nov 2025
Viewed by 1043
Abstract
Two previously undescribed highly oxygenated cembrane-type diterpenes, namely sarcocraol A (1) and sarcocraol B (2), along with five known compounds (37), have been isolated from the soft coral Sarcophyton crassocaule collected off Ximao Island in [...] Read more.
Two previously undescribed highly oxygenated cembrane-type diterpenes, namely sarcocraol A (1) and sarcocraol B (2), along with five known compounds (37), have been isolated from the soft coral Sarcophyton crassocaule collected off Ximao Island in the South China Sea. Their structures were determined through comprehensive spectroscopic analysis, QM-NMR calculations, TDDFT-ECD computation, X-ray diffraction analysis, and by comparison with literature data. Plausible biosynthetic pathways for these compounds were also proposed. All compounds were evaluated for peroxisome proliferator-activated receptors (PPARs) transcriptional activity using luciferase assay. The bioassay results demonstrated that compound 1 exhibits selective PPAR-γ agonistic activity. Furthermore, it promoted glucose uptake in HepG2 cells by 1.18-, 1.45-, and 1.90-fold at concentrations of 2.5, 5, and 10 μM, respectively, whereas rosiglitazone (10 μM) produced a 2.47-fold increase over the induced control. Compound 1 at 10 μM induced mild lipid accumulation in 3T3-L1 cells, showing a 1.63-fold increase relative to the control, which was much lower than the 3.28-fold increase observed in rosiglitazone (10 μM) group indicating its potential antidiabetic properties. These findings suggested that compound 1 could be a promising lead for the development of antidiabetic agents. Full article
(This article belongs to the Special Issue Natural Products from Soft Corals and Their Associated Microbes)
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