Discoveries of Bioactive Compounds from Algae

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Biotechnology Related to Drug Discovery or Production".

Deadline for manuscript submissions: closed (1 March 2024) | Viewed by 2666

Special Issue Editor

Special Issue Information

Dear Colleagues,

Bioactive compounds derived from algae still comprise an important and active area of research in the field of drug discovery. This Special Issue of Marine Drugs invites scholars to submit research into algae and aims to highlight new isolation and structural elucidation approaches, and developments in drug discovery, synthesis and medicinal chemistry, structural methods, chemical biology and biotechnology, and genomic tools. Additionally, we will publish studies on metabolomics and bioassay-guided and chemical profilin methodologies to expedite discoveries and advance potential therapeutics. This Special Issue invites reviews and original contributions in any of these areas.

Prof. Dr. Sylvia Urban
Guest Editor

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Keywords

  • algae
  • drug discovery
  • medicinal chemistry
  • structural methods
  • chemical approaches
  • metabolomics

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Published Papers (1 paper)

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Research

22 pages, 2121 KiB  
Article
An Eco-Friendly Extraction and Purification Approach for Obtaining Active Ingredients for Cosmetics from Two Marine Brown Seaweeds
by Leslie Gager, Solène Connan, Stéphane Cérantola, Sylvain Petek, Céline Couteau, Laurence Coiffard and Valérie Stiger-Pouvreau
Mar. Drugs 2024, 22(3), 112; https://doi.org/10.3390/md22030112 - 28 Feb 2024
Cited by 3 | Viewed by 2342
Abstract
Brown seaweeds are attracting attention due to their richness in bioactive compounds, in particular, their phlorotannins. We present here a case study of two Fucales, Ascophyllum nodosum and Halidrys siliquosa, sustainably collected, to produce active polyphenols for the cosmetics sector. Phenolic contents of [...] Read more.
Brown seaweeds are attracting attention due to their richness in bioactive compounds, in particular, their phlorotannins. We present here a case study of two Fucales, Ascophyllum nodosum and Halidrys siliquosa, sustainably collected, to produce active polyphenols for the cosmetics sector. Phenolic contents of crude extracts, obtained by Accelerated Solvent Extraction (ASE), were more elevated in H. siliquosa at 100.05 mg/g dry weight (DW) than in A. nodosum (29.51 mg/g DW), considering 3 cycles with cell inversion. The temperature of extraction for a high phenolic content and high associated antioxidant activities close to positive controls was 150 °C for both algae and the use of only one cycle was enough. A semi-purification process using Solid-phase Extraction (SPE) was carried out on both ASE crude extracts (one per species). The majority of phlorotannins were found in the ethanolic SPE fraction for A. nodosum and the hydroethanolic one for H. siliquosa. The SPE process allowed us to obtain more concentrated fractions of active phenolic compounds (×1.8 and 2 in A. nodosum and H. siliquosa, respectively). Results are discussed in regard to the exploitation of seaweeds in Brittany and to the research of sustainable processes to produce active natural ingredients for cosmetics. Full article
(This article belongs to the Special Issue Discoveries of Bioactive Compounds from Algae)
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