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Marine Natural Products Against Inflammatory-Based Diseases

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Pharmacology".

Deadline for manuscript submissions: 31 October 2026 | Viewed by 1033

Special Issue Editors


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Guest Editor
Department of Pharmacological and Biomolecular Sciences “Rodolfo Paoletti”, University of Milan, Milan, Italy
Interests: lipoproteins; marine fish proteins; fish oil; functional foods; atherosclerosis; animal models; microbiota
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Food and Drug, University of Parma, Parco Area delle Scienze, 27/A, 43124 Parma, Italy
Interests: atherosclerosis; inflammatory; functional foods

Special Issue Information

Dear Colleagues,

Inflammation is a conserved process that involves the activation of immune and non-immune cells, and the secretion of nitric oxide and pro-inflammatory cytokines aimed at protecting the host from pathogens and injuries and supporting tissue repair and recovery. Nevertheless, unresolved or sterile inflammation is responsible for the promotion of “low-grade systemic chronic inflammation”, a condition characterized by tissue and organ damage, metabolic disorders, i.e., atherosclerosis, type-2 diabetes, and obesity, and an increased predisposition to diverse inflammatory-based diseases, such as neurodegenerative pathologies, rheumatoid arthritis, inflammatory bowel diseases and cancer. Different studies have demonstrated that more dietary components may positively impact modifiable risk factors for chronic human syndromes. With marine species comprising approximately one-half of the global biodiversity, the ocean offers a wonderful resource for novel compounds, which may improve the health of the worldwide population. Moreover, several decades of research have documented that EPA and DHA exert triglyceride-lowering and antithrombotic effects, and play a relevant role in the resolution of inflammatory processes, being the precursors of specialized pro-resolving mediators (SPMs).

The aim of this Special Issue is to gather new information regarding the therapeutic applications of marine natural products against inflammatory-based diseases.

Dr. Cinzia Parolini
Prof. Dr. Elda Favari
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • N-3 PUFA
  • marine-derived ingredients
  • nutraceutical
  • triglycerides
  • cardiovascular diseases
  • obesity
  • metabolic syndrome
  • neurodegenerative disease
  • rheumatoid arthritis
  • inflammatory bowel diseases
  • cancer

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Published Papers (1 paper)

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Research

23 pages, 10031 KB  
Article
From Sea to Cell: Ascophyllum nodosum and Fucus vesiculosus Extracts Attenuate NF-κB-Mediated Inflammation and Protect Intestinal Barrier Integrity—A Comprehensive Analysis Applying In Vitro and In Vivo Models
by Lea Karlsberger, Nadiia Sadova, Mara Heckmann, Fanny Serenius, Annika Meinander, Julia Kirchsteiger, Alice König, Bettina Schwarzinger, Bernhard Blank-Landeshammer, Stephanie Ladirat and Julian Weghuber
Mar. Drugs 2026, 24(5), 182; https://doi.org/10.3390/md24050182 - 19 May 2026
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Abstract
The restriction of antimicrobial growth promoters in livestock production has intensified the search for nutritional strategies that support intestinal health while modulating inflammatory processes. Chronic or dysregulated inflammation can impair gut function and animal performance, highlighting the need for functional feed additives. Brown [...] Read more.
The restriction of antimicrobial growth promoters in livestock production has intensified the search for nutritional strategies that support intestinal health while modulating inflammatory processes. Chronic or dysregulated inflammation can impair gut function and animal performance, highlighting the need for functional feed additives. Brown macroalgae are rich in bioactive compounds with immunomodulatory properties, though their mechanisms remain incompletely understood. In this study, the anti-inflammatory and barrier-protective effects of aqueous extracts from Ascophyllum nodosum (AN) and Fucus vesiculosus (FV) were investigated using complementary in vitro and in vivo models. Extracts were prepared by aqueous solid–liquid extraction and tested in lipopolysaccharide (LPS)-stimulated RAW264.7 and THP-1 macrophages, HEK-Blue TLR4 reporter cells, and Drosophila melanogaster models of intestinal inflammation and infection. Both extracts significantly reduced LPS-induced nitric oxide production in RAW264.7 macrophages in a concentration-dependent manner. In THP-1 macrophages, AN and FV attenuated secretion of inflammatory mediators, including TNF-α, IL-6, IL-33, CXCL9, CXCL10, CXCL11, and CCL7. Reporter assays demonstrated selective inhibition of TLR4-dependent NF-κB activation. In Drosophila melanogaster, supplementation reduced intestinal barrier disruption, mortality, and infection-induced immune activation. Overall, AN and FV attenuate inflammatory signaling and protect intestinal integrity via TLR4-dependent NF-κB inhibition, supporting their potential as functional feed additives to enhance gut health and resilience in livestock. Full article
(This article belongs to the Special Issue Marine Natural Products Against Inflammatory-Based Diseases)
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