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Marine Drugs
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Marine Compounds as Cosmetic Ingredients
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Marine Compounds as Cosmetic Ingredients

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: 31 August 2026 | Viewed by 2268

Special Issue Editors

Dr. Erika Baldini

E-Mail Website
Guest Editor
Department of Life Sciences and Biotechnology, Faculty of Medicine, Pharmacy and Prevention, University of Ferrara, Via Luigi Borsari 46, 44121 Ferrara, Italy
Interests: microplastics; antioxidant; sunscreen; cosmetics; pharmaceutical
Dr. Elisa Durini

E-Mail Website
Guest Editor
Department of Life Sciences and Biotechnology, Faculty of Medicine, Pharmacy and Prevention, University of Ferrara, Via Luigi Borsari 46, 44121 Ferrara, Italy
Interests: sunscreen; antioxidant; hyaluronic acid; cosmetics

Special Issue Information

Dear Colleagues,

Marine organisms represent a rich source of bioactive compounds with diverse chemical structures and unique biological activities, making them highly attractive for the development of novel cosmetic ingredients. Over the past few decades, marine-derived compounds have gained increasing attention for their potential applications in skincare, including anti-aging, UV protection, hydration and antioxidant effects.

This Special Issue aims to highlight the potential of marine compounds as innovative cosmetic ingredients. We welcome contributions focusing on the discovery, characterization and application of marine bioactives, as well as studies involving innovative delivery systems, formulation strategies and efficacy testing in advanced in vitro or in vivo skin models.

Submissions that explore synergistic effects between marine compounds and conventional or innovative cosmetic agents, as well as those focusing on sustainable sourcing, biotechnological production and regulatory considerations, are particularly encouraged.

We invite researchers from academia and industry to submit original research articles or reviews that contribute to the scientific understanding and application of marine compounds in the cosmetic field.

Dr. Erika Baldini
Dr. Elisa Durini
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine compounds
  • cosmetic ingredients
  • skincare
  • formulation strategies
  • sustainable sourcing

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Published Papers (2 papers)

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Research

17 pages, 6283 KB  
Article
Isaridin E Protects Against UVB-Induced Photoaging by Activating Wnt/β-Catenin Signaling Pathway and Alleviating Mitochondrial Dysfunction
by Yaosheng Liu, Weizhen Li, Zeen Yang, Hui Long, Sufen Cai, Changjie Sun, Yu Xiong, Yunqi Zhang, Yumei Liu, Guangpu Luo, Senhua Chen and Tie Zhao
Mar. Drugs 2026, 24(3), 112; https://doi.org/10.3390/md24030112 - 18 Mar 2026
Cited by 1 | Viewed by 752
Abstract
Mitochondrial dysfunction is a major contributor to skin photoaging. Activation of the Wnt/β-catenin pathway, a key regulator of developmental processes, can improve mitochondrial abnormalities associated with pathology. Therefore, the Wnt/β-catenin pathway emerges as a key therapeutic target in the context of photoaging. Isaridin [...] Read more.
Mitochondrial dysfunction is a major contributor to skin photoaging. Activation of the Wnt/β-catenin pathway, a key regulator of developmental processes, can improve mitochondrial abnormalities associated with pathology. Therefore, the Wnt/β-catenin pathway emerges as a key therapeutic target in the context of photoaging. Isaridin E (ISE), a marine-derived natural product with a novel structure, exhibits potent antiplatelet and anti-inflammatory activities. We sought to examine the anti-senescence effects of ISE on fibroblasts in photoaged skin. In vitro, ISE improved UVB-induced fibroblast damage in a dose-dependent manner, restoring cell viability, reducing β-galactosidase accumulation, and suppressing SASP factor production. In a photoaging mouse model, ISE markedly decreased skin thickness, increased dermal collagen expression, and reduced SASP levels in skin tissues. ISE significantly improved fibroblast energy production deficits and mitochondrial dysfunction. RNA sequencing and Western blotting demonstrated that UVB irradiation significantly suppressed Wnt/β-catenin signaling activity, whereas ISE dose-dependently restored pathway activation. Using GSK-3β-targeted siRNA, we showed that the anti-photoaging effects of ISE are mediated via the Wnt/β-catenin pathway. ISE appears to counteract photoaging by enhancing Wnt/β-catenin activity and improving mitochondrial function. Full article
(This article belongs to the Special Issue Marine Compounds as Cosmetic Ingredients)
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21 pages, 6142 KB  
Article
Anti-Photoaging Effects of a Polysaccharide from Kappaphycus alvarezii In Vitro and In Vivo
by Yixuan Lai, Yuan Wang, Abdul Mueed, Peng Shu, Lijun You and Jiangming Zhong
Mar. Drugs 2026, 24(2), 87; https://doi.org/10.3390/md24020087 - 21 Feb 2026
Cited by 1 | Viewed by 963
Abstract
The red alga Kappaphycus alvarezii is a rich source of polysaccharides, but their high molecular weight limits skin permeability and bioavailability. To address this, we employed a free-radical degradation method to produce a low-molecular-weight polysaccharide, KP-90. Evaluation in UVB-irradiated HaCaT cells and UVA-irradiated [...] Read more.
The red alga Kappaphycus alvarezii is a rich source of polysaccharides, but their high molecular weight limits skin permeability and bioavailability. To address this, we employed a free-radical degradation method to produce a low-molecular-weight polysaccharide, KP-90. Evaluation in UVB-irradiated HaCaT cells and UVA-irradiated human dermal fibroblasts demonstrated that KP-90 significantly enhanced cell viability and mitigated oxidative stress by suppressing reactive oxygen species and malondialdehyde, while restoring antioxidant enzymes (SOD, CAT and GSH-Px). Furthermore, KP-90 downregulated matrix metalloproteinases (MMP-1, -3, -9) and pro-inflammatory cytokines (TNF-α, IL-6, IL-1β), thereby reducing extracellular matrix degradation and inflammation. These in vitro findings were corroborated in a UVB/UVA-irradiated nude mice model, where KP-90 alleviated epidermal hyperplasia, increased collagen I and hyaluronic acid synthesis, and improved visible signs such as wrinkles and skin laxity. These findings identify KP-90 against skin photoaging and provide a strategic approach for valorization underexploited marine biomass. Full article
(This article belongs to the Special Issue Marine Compounds as Cosmetic Ingredients)
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