Genomics, Proteomics and Metabolics of Extremophiles

Dear Colleagues,

While we continue to discover more about extremophiles, there is still much to learn about how microbes live and thrive in extreme environments. These environments stress the microbial community, individual microbes, and their cellular systems in a variety of ways. As we think about what it takes to adapt, we have to acknowledge that these environments contain a large diversity of organisms and, in a way, they must work together to survive. Even on the cellular level, proteins and other biomolecules must interact to compensate for the extreme conditions. On all levels, there are common microbial and molecular strategies for survival in these environments.

This issue will focus on adaptation strategies for the extremes: high and low temperatures, high and low pressures, and high salinity. We are inviting researchers to contribute original research and review articles that will further expand our knowledge of microbial (Archaea, Bacteria, or Eukaryotic) adaptation, from the organismal level to the protein level. Potential topics include, but are not limited to the following:

• Metagenomic analysis of microbial populations from extreme environments
• Analysis of interacting microbial populations: symbiosis, mutualism, commensalism, parasitism
• Intracellular signaling or cell-to-cell communications affected by extreme living environments
• Protein or biomolecule adaptations that help cells survive and thrive in their extreme environments
• Metabolic pathways that are required for survival or to improve survivability in extreme environments

Dr. Caryn Evilia
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• Microbial adaptation
• Protein adaptation
• Cell signaling
• Metabolism
• Microbial strategies