Research on Cell Plasticity and Tissue Remodeling in the Cardiovascular System
A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Clinical Medicine, Cell, and Organism Physiology".
Deadline for manuscript submissions: closed (1 October 2021) | Viewed by 10581
Special Issue Editor
Special Issue Information
Dear Colleagues,
Background: Cardiovascular disease constitutes the main cause of death in the developed world. Treatment options are very limited and typically focus on the management of symptoms. Remodeling of the cardiovascular system upon injury constitutes a critical step in disease progression and can mark the difference between complete regeneration/repair or pathological remodeling. It is critical to understand the mechanisms of cell plasticity and tissue remodeling in the damaged cardiovascular system to develop new and personalized therapeutic approaches.
Aims and scope: The aim of this Special Issue is to present a collection of original research articles and comprehensive reviews focusing on:
- Mechanisms of cardiac regeneration (including but not limited to cardiac stem cells, epigenetic mechanisms, and in vivo reprogramming);
- Mechanisms of pathologic vascular remodeling (atherosclerotic plaque development, endothelial-to-mesenchymal transition, and stenosis);
- Novel therapeutic development for cardiovascular regeneration or to prevent pathologic remodeling;
- Inflammation and its role in promoting and stopping pathological cardiovascular tissue remodeling.
History: Over the last two decades, it has become increasingly clear that the cardiovascular system is not quiescent and contains significant populations of progenitor cells to undergo repair and homeostasis. We have also learned that mature cells, such as cardiomyocytes or endothelial cells, possess a certain degree of plasticity, allowing them to dedifferentiate and/or transdifferentiate into other related cell types. These homeostatic remodeling mechanisms play important roles when the cardiovascular tissue is damaged or as we age, and can contribute very significantly to pathological remodeling and disease progression.
Cutting-edge research: We are inviting submissions on cutting-edge research investigating mechanisms of cell plasticity and tissue remodeling in the cardiovascular system, or dealing with novel therapeutics aimed at modulating these tissue remodeling pathways.
What kind of papers we are soliciting: We are looking for original research articles and comprehensive reviews focusing on the last decade of advances on this topic.
Dr. Aitor Aguirre
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cardiovascular
- stem cells
- cell reprogramming
- cell plasticity
- regeneration
- inflammation
- tissue remodeling
- epigenetic
- endothelial
- in vivo reprogramming
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