Personalized Urologic Surgery: Innovation and Strategies

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Therapy and Drug Delivery".

Deadline for manuscript submissions: 20 April 2026 | Viewed by 409

Special Issue Editors


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Guest Editor
Department of Urology, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, 00168 Rome, Italy
Interests: urinary oncology; urinary stones; minimally invasive surgery; reconstructive surgery; endourology; renal cancer
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Urology, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, 00168 Rome, Italy
Interests: urinary oncology; minimally invasive surgery; endoscopic surgery; endourology; bladder cancer; renal cancer

Special Issue Information

Dear Colleagues,

In recent decades, there have been extensive developments in the surgical management of benignant and malignant urinary pathologies. Novel treatment approaches are gaining traction, and more and more mature results are underlining the relevance of mini-invasivity in any kind of urological surgery. Today, surgical stress and invasivity are progressively reducing movement. Additionally, robotic platform diffusion, single-port access, extraperitoneal approaches, digital endourology, and lasers improvements are changing scenarios in cancers and in stone management. 

Machine learning and artificial intelligence will provide information and integrate surgical procedures and therapy planning. Moreover, quality of life, precise surgical patient selection, and early recovery have similarly gained popularity in clinical practice, with a renewed focus on personalized and tailored interventions to reduce morbidity and improve quality of life. Finally, new insights derived from newer systemic therapies and stereotactic treatment are completing our understanding of surgical procedures to provide multimodal approaches in different clinical scenarios.

This Special Issue, entitled "Personalized Urologic Surgery: Innovation and Strategies", presents an up-to-date platform to underline the relevance of patient-centered personalized management from a preoperative to intraoperative and postoperative point of view. Original research and reviews are welcome.

Dr. Nazario Foschi
Dr. Pierluigi Russo
Guest Editors

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Keywords

  • urologic surgery
  • urinary oncology
  • minimally invasive surgery
  • endoscopic surgery
  • endourology
  • robotic surgery
  • personalized surgery

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Published Papers (1 paper)

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Research

11 pages, 479 KB  
Article
Incisional Negative-Pressure Wound Therapy Versus Standard Dressing for the Prevention of Surgical Site Complications Following Radical Cystectomy
by Fabio Traunero, Arianna Biasatti, Giulio Rossin, Andrea Piasentin, Federico Zorzi, Michele Rizzo, Paolo Umari, Tommaso Cai, Alessandro Zucchi and Giovanni Liguori
J. Pers. Med. 2025, 15(12), 581; https://doi.org/10.3390/jpm15120581 - 30 Nov 2025
Viewed by 280
Abstract
Background/Objectives: Radical cystectomy (RC) is a complex urologic procedure that, when performed using an open surgical approach, carries a high risk of surgical site complications (SSCs), which can lead to prolonged recovery, increased healthcare costs, and higher morbidity. Incisional negative-pressure wound therapy (iNPWT) [...] Read more.
Background/Objectives: Radical cystectomy (RC) is a complex urologic procedure that, when performed using an open surgical approach, carries a high risk of surgical site complications (SSCs), which can lead to prolonged recovery, increased healthcare costs, and higher morbidity. Incisional negative-pressure wound therapy (iNPWT) has demonstrated benefits in enhancing wound healing in various surgical settings, but its effectiveness in the context of RC remains underexplored. This study aimed to evaluate the impact of iNPWT on the incidence of SSCs following RC compared to standard surgical dressings using the PICO® system. Methods: A cohort of 146 patients who underwent RC between 2015 and 2021 was divided into two groups: those treated with standard dressings (Group 1, n = 80) and those who received iNPWT (Group 2, n = 66). Patient-related, surgical, and pathological variables were compared between the groups. Categorical variables were analyzed using the chi-square or Fisher’s exact test, while continuous variables were assessed using Student’s t-test. Univariate logistic regression models were applied to evaluate the association between iNPWT use and 90-day SSCs, as well as to identify risk factors for complications. Results: Group 2 (iNPWT) had a higher prevalence of chronic comorbidities, including chronic kidney disease, but fewer active smokers compared to Group 1. Higher body mass index, prolonged operative time, and uncontrolled diabetes were significantly associated with the development of SSCs. The incidence of SSCs within 90 days was significantly lower in the iNPWT group (7.6%) compared to the standard dressing group (22.5%) (p = 0.03). iNPWT use was associated with a substantially reduced risk of SSCs (OR: 0.282), demonstrating a protective effect. Conclusions: Prophylactic application of iNPWT following RC significantly reduced the incidence of surgical site complications compared to standard dressing. These findings support the potential of iNPWT as a valuable adjunct in perioperative wound management. While encouraging, these results warrant validation in prospective, randomized studies. Tailored postoperative strategies and identification of patient-specific risk factors remain essential components in SSC prevention and reflect the growing importance of precision medicine in surgical oncology. Full article
(This article belongs to the Special Issue Personalized Urologic Surgery: Innovation and Strategies)
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