Vascular Reconstruction, Imaging and Personalized Medicine

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Clinical Medicine, Cell, and Organism Physiology".

Deadline for manuscript submissions: closed (15 July 2022) | Viewed by 2577

Special Issue Editors


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Guest Editor
Faculty of Fire Safety Engineering, The Main School of Fire Service, 01-629 Warsaw, Poland
Interests: dispersion; CFD simulation; smoke spread simulation; jet ventilation; duct ventilation; LPG leakage
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Co-Guest Editor
Department of Medical Biotechnology, Jagiellonian University, Krakow, Poland
Interests: in virto and in vivo methods; animal studies; human studies; dose-response effect
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Special Issue Information

Dear Colleagues,

The human cardiac system is a set of connected vessels, and one surgical intervention can disturb blood hemodynamics in the whole system. Therefore, it is essential to predict the character of blood hemodynamic changes before and after surgical intervention. Currently, physicians and engineers are working together to address the aforementioned issues, often with the use of human or animal models as well as their digital presentation in numerical models. As these approaches may reduce morbidity or mortality, early diagnosis, and treatment—including preoperative care and surgical intervention—is mandatory. Therefore, the topic of blood hemodynamic reconstruction in numerical and experimental models combines all the above-mentioned aspects and allows the dissemination of valuable results.

This Special Issue of the Journal of Personalized Medicine will be devoted to providing a focused perspective in specific areas of blood hemodynamic reconstruction, with topics including but not limited to:

  • Computational fluid dynamic techniques for blood hemodynamic reconstruction;
  • Bioreactor for artificial vessels and human tissues;
  • Optimization of the process of vascular implant placement;
  • Fluid–structure interaction of moving wall and blood components.

Prof. Dr. Andrzej Polanczyk
Dr. Aleksandra Piechota-Polanczyk
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • vascular implants
  • image processing
  • computer simulation
  • blood hemodynamic reconstruction
  • artificial vessels
  • AAA

Published Papers (1 paper)

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Research

24 pages, 11709 KiB  
Article
Patient-Specific Image-Based Computational Fluid Dynamics Analysis of Abdominal Aorta and Branches
by Alin-Florin Totorean, Iuliana-Claudia Totorean, Sandor Ianos Bernad, Tiberiu Ciocan, Daniel Claudiu Malita, Dan Gaita and Elena Silvia Bernad
J. Pers. Med. 2022, 12(9), 1502; https://doi.org/10.3390/jpm12091502 - 14 Sep 2022
Cited by 4 | Viewed by 2202
Abstract
The complicated abdominal aorta and its branches are a portion of the circulatory system prone to developing atherosclerotic plaque and aneurysms. These disorders are closely connected to the changing blood flow environment that the area’s complicated architecture produces (between celiac artery and iliac [...] Read more.
The complicated abdominal aorta and its branches are a portion of the circulatory system prone to developing atherosclerotic plaque and aneurysms. These disorders are closely connected to the changing blood flow environment that the area’s complicated architecture produces (between celiac artery and iliac artery bifurcation); this phenomenon is widespread at arterial bifurcations. Based on computed tomography angiography (CTA) scans, this current work offers a numerical analysis of a patient-specific reconstruction of the abdominal aorta and its branches to identify and emphasize the most likely areas to develop atherosclerosis. The simulations were run following the heart cycle and under physiological settings. The wall shear stress (WSS), velocity field, and streamlines were examined. According to the findings, complex flow is primarily present at the location of arterial bifurcations, where abnormal flow patterns create recirculation zones with low and fluctuating WSS (<0.5 Pa), which are known to affect endothelial homeostasis and cause adverse vessel remodeling. The study provides a patient-specific hemodynamic analysis model, which couples in vivo CT imaging with in silico simulation under physiological circumstances. The study offers quantitative data on the range fluctuations of important hemodynamic parameters, such as WSS and recirculation region expansion, which are directly linked to the onset and progression of atherosclerosis. The findings could also help drug targeting at this vascular level by understanding blood flow patterns in the abdominal aorta and its branches. Full article
(This article belongs to the Special Issue Vascular Reconstruction, Imaging and Personalized Medicine)
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