Precision Medicine Approaches for Public Health Challenges

Dear Colleagues,

Precision medicine is reshaping how we address major public health challenges by integrating biomarkers, omics data, advanced imaging, and digital tools to tailor both prevention strategies and therapeutic interventions. From the early genomic era to today’s multi-omics and AI-driven models, precision-based approaches have progressively moved from experimental settings to guidelines, screening programs, and targeted treatments across a wide range of diseases. Precision medicine is transforming how we understand, prevent, and manage disease by moving beyond the “one-size-fits-all” approach toward tailored risk assessment, diagnostics, and interventions.

This Special Issue focuses on how diagnostics in personalized medicine can inform risk stratification, guide individualized therapies, and ultimately support population-level planning, resource allocation, and the reduction in health inequalities. We are particularly interested in studies combining molecular profiling, pharmacogenomics, digital health, AI-based decision support, and real-world data to optimize early detection, treatment selection, therapeutic monitoring, and long-term follow-up. We welcome original research, implementation studies, methodological papers, and reviews addressing precision approaches for prevention and therapy in noncommunicable diseases, infectious diseases, mental health, multimorbidity, and One Health contexts.

Dr. Jacopo Dolcini
Dr. Manuela Chiavarini
Guest Editors

Manuscript Submission Information

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