Immunotherapy and Targeted Therapy in Gynecologic Cancer: Current Status and Challenges
A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Molecular Targeted Therapy".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 22
Special Issue Editors
Interests: gynecological tumors; genito-urinary tumors; immunotherapy; PARPis; meta-analysis; biomarkers
2. Gynecologic Oncology Unit, IRCCS Istituto Tumori “Giovanni Paolo II”, 70124 Bari, Italy
Interests: gynecological oncology; gynecology; obstetrics; cancer; uterine cancer; ovarian cancer; cancer therapy
Special Issue Information
Dear Colleagues,
The integration of immunotherapy and targeted agents has redefined the treatment landscape for many solid tumors, and gynecologic cancers are no exception. In recent years, immune checkpoint inhibitors and molecular-targeted therapies have demonstrated promising activity in selected subgroups of patients, particularly those with high PD-L1 expression, microsatellite instability, or HPV-driven pathogenesis. However, several gynecologic malignancies—especially rare and understudied subtypes—still lead to poor prognoses and lack effective treatment options.
This Special Issue will highlight both the achievements and ongoing challenges in the application of personalized approaches to immunotherapy and targeted treatment in gynecologic oncology. A central focus will be placed on the role of predictive and prognostic biomarkers in guiding therapy selection, monitoring treatment responses, and anticipating resistance. Precision oncology strategies—including multi-omic profiling, individualized risk stratification, and real-world implementation—will be explored to enhance therapeutic outcomes across diverse gynecologic tumors.
We welcome submissions of original research articles, systematic reviews, meta-analyses, and translational studies investigating immunotherapy, targeted therapies, biomarker discovery, personalized treatment algorithms, and the development of clinical trials within a precision medicine framework. By gathering multidisciplinary contributions, we hope to provide an updated and comprehensive resource for optimizing patient-tailored care in gynecologic oncology.
Dr. Brigida Anna Maiorano
Guest Editor
Dr. Mauro Francesco Pio Maiorano
Guest Editor Assistant
Manuscript Submission Information
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Keywords
- immunotherapy
- targeted therapy
- gynecologic cancer
- vulvar cancer
- biomarkers
- immune checkpoint inhibitors
- HPV-related tumors
- personalized oncology
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