Personalized Oncology in Gastrointestinal Cancer: Emerging Therapies and Challenges

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Therapy and Drug Delivery".

Deadline for manuscript submissions: closed (20 April 2026) | Viewed by 696

Special Issue Editor


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Guest Editor
Medical Oncology, AO “S. Croce and Carle”, Cuneo, Italy
Interests: gastrointestinal cancers; immunotherapy; targeted therapy; chemotherapy; microsatellite instability; driver mutations

Special Issue Information

Dear Colleagues,

This Special Issue on “Personalized Oncology in Gastrointestinal Cancer: Emerging Therapies and Challenges” will mainly focus on analyzing present and future approaches for the treatment of gastrointestinal (GI) cancer patients, with a glimpse into novel perspectives and future challenges in clinical practice. GI cancers are one of the most common worldwide cause of cancer-related death. They include a wide spectrum of neoplasms, including esophageal, gastric, hepatic, biliary, pancreatic, small bowel and large bowel as well as rectal cancers. In the last decade, significant improvements have been made in the prognosis of patients affected by these tumors thanks to the development of new treatments, which include cytotoxic drugs, targeted therapies, and immunotherapy. Recently, emerging and novel biomarkers have been identified and validated with a huge impact on patients’ outcomes and improving the treatment landscape. Despite these advances, GI cancers still represent a major public health problem worldwide; hence, it is mandatory to develop novel therapeutic approaches. We cordially invite experts in the field to submit original research or review articles to better understand and explore this important topic.

We look forward to receiving your contributions.

Dr. Carmelo Laface
Guest Editor

Manuscript Submission Information

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Keywords

  • gastrointestinal cancers
  • immunotherapy
  • targeted therapy
  • chemotherapy
  • microsatellite instability
  • driver mutations

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Published Papers (1 paper)

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Review

15 pages, 1238 KB  
Review
Antibody–Drug Conjugates in Gastrointestinal Oncology: Clinical Efficacy and Inpatient Toxicity Management
by Ashish Sharma, Harendra Kumar, Ruchir Paladiya, Rajvardhan Sisodia, Hareesha Rishab Bharadwaj, Islam Mohamed, Saqr Alsakarneh, Umar Hayat, Sneh Sonaiya, Hema Sameera Pinnam, Hassam Ali and Dushyant Singh Dahiya
J. Pers. Med. 2026, 16(4), 195; https://doi.org/10.3390/jpm16040195 - 1 Apr 2026
Viewed by 480
Abstract
Antibody–drug conjugates (ADCs) are reshaping the therapeutic approach to advanced gastrointestinal cancers by integrating tumor-specific monoclonal antibodies with potent cytotoxic payloads to improve targeted tumor cell destruction while minimizing systemic exposure. Compared to traditional chemotherapy, trastuzumab deruxtecan has significantly improved objective response rates [...] Read more.
Antibody–drug conjugates (ADCs) are reshaping the therapeutic approach to advanced gastrointestinal cancers by integrating tumor-specific monoclonal antibodies with potent cytotoxic payloads to improve targeted tumor cell destruction while minimizing systemic exposure. Compared to traditional chemotherapy, trastuzumab deruxtecan has significantly improved objective response rates and overall survival in HER2-positive gastric and gastroesophageal junction tumors after trastuzumab-based therapy. This supports its role as an important second-line or later treatment option. The ongoing advancement of ADCs targeting CLDN18.2, TROP2, and CEACAM5 indicates that this therapeutic category will continue to expand across gastrointestinal neoplasms. Nonetheless, these advancements are accompanied by a specific and clinically significant toxicity profile. Hematologic suppression, gastrointestinal side effects, hepatotoxicity, and notably interstitial lung disease (ILD) are essential consequences that may need inpatient assessment and care. Interstitial lung disease (ILD), although uncommon, may be severe or lethal if not identified immediately and treated swiftly with medication cessation and corticosteroids. In hospitalized patients, distinguishing ADC-related toxicity from infection or disease progression is often difficult owing to overlapping clinical manifestations, requiring meticulous evaluation and interdisciplinary cooperation. As ADCs are integrated into earlier treatment lines and across a broader patient population, hospital systems must evolve to ensure prompt identification, consistent management protocols, and efficient collaboration between oncology and inpatient teams. This study analyzes the mechanisms, clinical effectiveness, and safety profile of ADCs in gastrointestinal oncology, pointing out the importance of institutional preparedness to safely incorporate these medicines into standard clinical practice. These features also align ADC therapy with personalized medicine by emphasizing biomarker-guided patient selection and individualized toxicity monitoring. Full article
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