Antifungal Resistance 2.0

Dear Colleagues,

Antifungal resistance in clinically significant fungi deserves more attention than it is currently receiving for several reasons. While knowledge on primary antifungal resistance is increasing, secondary resistance tends to emerge for at least a number of antifungal drugs against certain fungal species. Secondary azole resistance in Aspergillus fumigatus and multidrug resistance in Candida auris are among the topics of current particular interest. Reference antifungal susceptibility testing methods have already provided standard tools for the detection of in vitro resistance, and current studies are promisingly leading to the determination of additional interpretive breakpoints. New data are being revealed in various studies on correlation of clinical outcomes with in vitro resistance, which remains of particular significance in the rational management of antifungal therapy. Unveiling molecular mechanisms of antifungal resistance and future perspectives on the use of molecular methods for detection of resistance in routine practice are of specific interest. Given the growing significance and awareness, as well as the recently emerging data, the aim of this Special Issue is to highlight the current status and to introduce recent findings of antifungal resistance observed in clinically significant fungi.

Prof. Dr. Sevtap Arikan-Akdagli
Guest Editor

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