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Pathogenic Mechanisms and Antifungal Drugs Research of Clinical Pathogenic Fungi
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Pathogenic Mechanisms and Antifungal Drugs Research of Clinical Pathogenic Fungi

A special issue of Journal of Fungi (ISSN 2309-608X). This special issue belongs to the section "Fungal Pathogenesis and Disease Control".

Deadline for manuscript submissions: 31 December 2026 | Viewed by 184

Editors

Dr. Rodrigo Rollin-Pinheiro

E-Mail Website
Guest Editor
Departamento de Microbiologia, Imunologia e Parasitologia, Faculdade de Ciências Médicas (FCM), Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro 20551-030, Brazil
Interests: fungal infection; glucosylceramide; host-pathogen interaction; fungal growth; biofilm; candida; sphingolipids; myriocin; antifungal drugs; drug repurposing
Dr. Daniel Clemente de Moraes

E-Mail Website
Guest Editor
Laboratório de Bioquímica Microbiana, Departamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro 21941-902, Brazil
Interests: antifungal resistance; antifungal drugs; biofilms; efflux pumps; yeasts
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Fungal infections have been emerging over the last decades, and their increasing frequency has become a major public health concern. The incidence of invasive mycoses is associated with several underlying health conditions, such as immunosuppression, history of surgeries, organ transplantation, chemotherapy, and diabetes. Considering that many of them might increase in population worldwide, healthcare professionals are likely to face a variety of fungal infections in the present and near future.

In addition, currently available antifungal therapy displays important limitations, such as toxicity and the increasing rates of antifungal resistance observed in clinical settings. For these reasons, there is an urgent need to investigate the mechanisms of fungal pathogenesis, as well as develop new antifungal drugs to improve the management of fungal infections.

This Special Issue aims to present and disseminate the most recent advances related to understanding the pathogenic mechanisms and strategies employed by fungi, as well as highlight new approaches to antifungal therapy. We consider contributions addressing how pathogenic fungi establish infections in humans and develop antifungal resistance, as well as studies on new approaches for antifungal therapy. 

Topics of interest for publication include, but are not limited to, the following:

  • Mechanism of virulence
  • Strategies of resistance to antifungal drugs
  • New substances with antifungal activity
  • The use of repurposing drugs against fungal infections

Dr. Rodrigo Rollin-Pinheiro
Dr. Daniel Clemente de Moraes
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Fungi is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • virulence
  • antifungals
  • repurposing drugs
  • fungi–host interaction
  • pathogenic fungi

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Published Papers (1 paper)

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Research

12 pages, 2405 KB  
Article
Non-Interventional, Retrospective, Multicenter Study on the Renal Safety of Liposomal Amphotericin B in Critically Ill Patients with Invasive Pulmonary Aspergillosis
by Borja Suberviola, Jose Peral Gutierrez de Ceballos, Maria Jose Asensio Martin, Cruz Soriano Cuesta, Rafael Zaragoza, Lorena Forcelledo, Iratxe Seijas and Miguel Santibanez
J. Fungi 2026, 12(7), 458; https://doi.org/10.3390/jof12070458 (registering DOI) - 23 Jun 2026
Abstract
Purpose: This study aims to determine the incidence of kidney injury associated with liposomal amphotericin B (L-AmB) treatment, based on RIFLE criteria, in patients admitted to the intensive care unit (ICU) with invasive pulmonary aspergillosis (IPA). Materials and Methods: A retrospective, multicenter observational [...] Read more.
Purpose: This study aims to determine the incidence of kidney injury associated with liposomal amphotericin B (L-AmB) treatment, based on RIFLE criteria, in patients admitted to the intensive care unit (ICU) with invasive pulmonary aspergillosis (IPA). Materials and Methods: A retrospective, multicenter observational study including patients treated with L-AmB for IPA while admitted to the ICU between 1 January 2015, and 31 December 2022. Results: A total of 65 patients were included. The prevalence of renal failure was 35.39%. Renal failure was mostly mild and reversible. The need for major surgery (OR 6.71; p = 0.121) and concomitant use of other nephrotoxic treatments (OR 2.5; p = 0.194) emerged as potential risk factors for the development of renal failure; however, neither association reached statistical significance. Overall mortality was 66.2%, significantly higher in the group with renal failure (82.6% vs. 57.1%; p = 0.03). Factors associated with mortality included concomitant use of other nephrotoxic agents (OR 4.51; p = 0.024) and development of renal failure (OR 3.66; p = 0.068). Duration of L-AmB treatment was not associated with mortality. Regarding creatinine recovery, all patients who developed renal failure but survived showed creatinine levels below 1.5 mg/dL after completion of treatment. Conclusions: Renal impairment was common in this high-risk population of critically ill patients, with renal function impairment in one-third of exposed patients, although most cases were mild. In this population, concomitant administration of other nephrotoxic drugs was associated with both renal failure and mortality. Treatment duration with L-AmB was not linked to mortality, and creatinine levels normalized after therapy completion. Full article
(This article belongs to the Special Issue Pathogenic Mechanisms and Antifungal Drugs Research of Clinical Pathogenic Fungi)
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