Treatment of Oral and Vulvovaginal Candidiasis by Natural Products

A special issue of Journal of Fungi (ISSN 2309-608X).

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 1539

Special Issue Editor


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Guest Editor
Departamento de Bioquímica, Instituto de Ciências Biológicas, Universidade Federal de Juiz de Fora (UFJF), Juiz de Fora, Brazil
Interests: natural products; antimicrobial activity; antifungal mechanism of action

Special Issue Information

Dear Colleagues,

The emergence of fungal infections is increasingly considered a public health problem, especially in immunocompromised or hospitalized patients with subjacent diseases. Yeasts of the genus Candida, belonging to the human microbiota and capable of becoming pathogenic upon an unbalance in the host immune system, are a major concern triggering, for example, inflammatory processes. These yeasts can cause various types of infections: localized or superficial, affecting the skin or mucous membranes, or more serious forms, such as systemic ones. Furthermore, the antifungal arsenal is reduced, especially with the increase in resistance, toxicity, and difficulty in therapeutic choice. Faced with the above, natural products may be an alternative in the treatment of fungal infections caused by these species, mainly for vulvovaginal and oral candidiasis.

Prof. Dr. Rodrigo Luiz Fabri
Guest Editor

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Keywords

  • Candida spp.
  • oral candidiasis
  • vulvovaginal candidiasis
  • natural products
  • antifungal activity

Published Papers (1 paper)

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Research

19 pages, 5107 KiB  
Article
Antifungal Activity and Type of Interaction of Melissa officinalis Essential Oil with Antimycotics against Biofilms of Multidrug-Resistant Candida Isolates from Vulvovaginal Mucosa
by Marina Ranđelović, Marina Dimitrijević, Suzana Otašević, Ljiljana Stanojević, Milica Išljamović, Aleksandra Ignjatović, Valentina Arsić-Arsenijević and Zorica Stojanović-Radić
J. Fungi 2023, 9(11), 1080; https://doi.org/10.3390/jof9111080 - 4 Nov 2023
Cited by 1 | Viewed by 1261
Abstract
(1) Background: Vulvovaginal candidosis (VVC) is a major therapy issue due to its high resistance rate and virulence factors such as the ability to form biofilms. The possibility of combining commonly used antifungals with natural products might greatly improve therapeutic success. (2) Methods: [...] Read more.
(1) Background: Vulvovaginal candidosis (VVC) is a major therapy issue due to its high resistance rate and virulence factors such as the ability to form biofilms. The possibility of combining commonly used antifungals with natural products might greatly improve therapeutic success. (2) Methods: A total of 49 vulvovaginal isolates, causative agents of recurrent VVC, were tested for their susceptibility to fluconazole, nystatin, and Melissa officinalis essential oil (MOEO). This examination included testing the antibiofilm potential of antifungals and MOEO and the determination of their types of interaction with mature biofilms. (3) Results: Antimicrobial testing showed that 94.4% of the Candida albicans isolates and all the Candida krusei isolates were resistant to fluconazole, while all strains showed resistance to nystatin. The same strains were susceptible to MOEO in 0.156–2.5 mg/mL concentrations. Additionally, the results revealed very limited action of fluconazole, while nystatin and MOEO reduced the amount of biofilm formed by as much as 17.7% and 4.6%, respectively. Testing of the combined effect showed strain-specific synergistic action. Furthermore, the lower concentrations exhibited antagonistic effects even in cases where synergism was detected. (4) Conclusions: This study showed that MOEO had a very good antibiofilm effect. However, combining MOEO with antimycotics demonstrated that the type of action depended on the choice of antifungal drugs as well as the applied concentration. Full article
(This article belongs to the Special Issue Treatment of Oral and Vulvovaginal Candidiasis by Natural Products)
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