Evolving Concepts of Pneumocystis Epidemiology, Host Specificity and Evolution
Deadline for manuscript submissions: 31 May 2024 | Viewed by 5265
Interests: epidemiology and molecular biology of fungal pathogens; antigenic variation and immune evasion; host-pathogen interactions; drug resistance; molecular diagnosis; Pneumocystis
Interests: mycology with focus on human pathogens; evolutionary cell biology; population genetics; host-pathogen interaction
Interests: pathology of infectious diseases with focus on viral, bacterial, and fungal infections of the respiratory tract of the pig; Pneumocystis in various mammal species; modern diagnostic methods in veterinary pathology
The WHO recently sounded the alarm, highlighting the rising threat of medically significant invasive fungal diseases worldwide, and released a list of 19 priority fungal pathogens, including Pneumocystis jirovecii, targeted for increased research. Since its first discovery in 1909, our understanding of Pneumocystis has undergone a dramatic evolution, including its taxonomic classification from a single protozoan species to a fungus of multiple species, its host range from only a few mammal species with no specificity to hundreds of mammal species with high specificity, and its pathogenic role from an obscure pathogen to a prominent cause of life-threatening pneumonia in immunocompromised patients.
Empowered by recent advances in genetics and genomics, our knowledge of Pneumocystis continues to evolve in various aspects, particularly in epidemiology, host specificity, and evolution. Some key evolving developments include frequent outbreaks of Pneumocystis pneumonia in transplant recipients, widespread colonization or subclinical infection in immunocompetent and immunodeficient hosts, growing incidence of coinfection of multiple Pneumocystis strains or species in the same host species, reduced host specificity of Pneumocystis among closely related host species, and discordant evolution of some Pneumocystis species with their host species.
The aim of this Special Issue is to foster and integrate scholarly contributions characterizing the new trend of Pneumocystis epidemiology in humans and animals (including laboratory, domesticated, and wild animals), demonstrating the changing pattern and molecular basis of host specificity of Pneumocystis and exploring the evolutionary dynamics of Pneumocystis from different host species.
Dr. Liang Ma
Dr. Ousmane H. Cissé
Dr. Christiane Weissenbacher-Lang
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- host specificity
- species evolution