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Exclusive Papers of the Editorial Board Members
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Exclusive Papers of the Editorial Board Members

A special issue of Journal of Nanotheranostics (ISSN 2624-845X).

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 24364

Special Issue Editor

Prof. Dr. Seyed Moein Moghimi

E-Mail Website
Guest Editor
1. Pharmaceutics and Nanomedicine, School of Pharmacy, Newcastle University, Newcastle upon Tyne NE1 7RU, UK
2. Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE1 7RU, UK
3. Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver, Denver, CO 80204, USA
Interests: nanomedicine; nanosafety; nanoparticle engineering; immunology; drug delivery

Special Issue Information

Dear Colleagues,

To celebrate the successful launch of Journal of Nanotheranostics (JNT), we are devoting this Special Issue of JNT to publishing a diverse selection of exclusive papers from the Editorial Board Members (EBMs). This Issue is intended to bring together expert opinion pieces, educational and critical reviews to put key research and regulatory topics in nanotheranostics into perspective and provide future direction for new investigators in order to push the field forward. In addition, this Special Issue of JNT will also consider innovative and original basic, translational and clinical research papers from the laboratories of our EBMs. All EBMs are invited to contribute, and all submissions will be rigorously peer reviewed.

Prof. Dr. Seyed Moein Moghimi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Nanotheranostics is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • advanced nanomaterials for biomedical applications
  • miniaturized systems for health care
  • nano-enabled sensing systems for target analyte detection
  • point-of-care systems for personalized health care
  • image-guided therapy
  • personalized nanomedicine
  • nano-enabled tissues and gene engineering
  • nanotechnology-based drug delivery systems
  • nano-pharmacology
  • nanobiotechnology for drug addiction

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  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (5 papers)

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Research

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17 pages, 5187 KiB  
Article
Improvements in Gold Nanorod Biocompatibility with Sodium Dodecyl Sulfate Stabilization
by Rossana Terracciano, Aobo Zhang, Mathieu L. Simeral, Danilo Demarchi, Jason H. Hafner and Carly S. Filgueira
J. Nanotheranostics 2021, 2(3), 157-173; https://doi.org/10.3390/jnt2030010 - 26 Aug 2021
Cited by 8 | Viewed by 5418
Abstract
Due to their well-defined plasmonic properties, gold nanorods (GNRs) can be fabricated with optimal light absorption in the near-infrared region of the electromagnetic spectrum, which make them suitable for cancer-related theranostic applications. However, their controversial safety profile, as a result of surfactant stabilization [...] Read more.
Due to their well-defined plasmonic properties, gold nanorods (GNRs) can be fabricated with optimal light absorption in the near-infrared region of the electromagnetic spectrum, which make them suitable for cancer-related theranostic applications. However, their controversial safety profile, as a result of surfactant stabilization during synthesis, limits their clinical translation. We report a facile method to improve GNR biocompatibility through the presence of sodium dodecyl sulfate (SDS). GNRs (120 × 40 nm) were synthesized through a seed-mediated approach, using cetyltrimethylammonium bromide (CTAB) as a cationic surfactant to direct the growth of nanorods and stabilize the particles. Post-synthesis, SDS was used as an exchange ligand to modify the net surface charge of the particles from positive to negative while maintaining rod stability in an aqueous environment. GNR cytotoxic effects, as well as the mechanisms of their cellular uptake, were examined in two different cancer cell lines, Lewis lung carcinoma (LLC) and HeLa cells. We not only found a significant dose-dependent effect of GNR treatment on cell viability but also a time-dependent effect of GNR surfactant charge on cytotoxicity over the two cell lines. Our results promote a better understanding of how we can mediate the undesired consequences of GNR synthesis byproducts when exposed to a living organism, which so far has limited GNR use in cancer theranostics. Full article
(This article belongs to the Special Issue Exclusive Papers of the Editorial Board Members)
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12 pages, 1896 KiB  
Article
A Proteomic Study on the Personalized Protein Corona of Liposomes. Relevance for Early Diagnosis of Pancreatic DUCTAL Adenocarcinoma and Biomarker Detection
by Luca Digiacomo, Francesca Giulimondi, Daniela Pozzi, Alessandro Coppola, Vincenzo La Vaccara, Damiano Caputo and Giulio Caracciolo
J. Nanotheranostics 2021, 2(2), 82-93; https://doi.org/10.3390/jnt2020006 - 11 Jun 2021
Cited by 11 | Viewed by 3658
Abstract
Due to late diagnosis, high incidence of metastasis, and poor survival rate, pancreatic cancer is one of the most leading cause of cancer-related death. Although manifold recent efforts have been done to achieve an early diagnosis of pancreatic cancer, CA-19.9 is currently the [...] Read more.
Due to late diagnosis, high incidence of metastasis, and poor survival rate, pancreatic cancer is one of the most leading cause of cancer-related death. Although manifold recent efforts have been done to achieve an early diagnosis of pancreatic cancer, CA-19.9 is currently the unique biomarker that is adopted for the detection, despite its limits in terms of sensitivity and specificity. To identify potential protein biomarkers for pancreatic ductal adenocarcinoma (PDAC), we used three model liposomes as nanoplatforms that accumulate proteins from human plasma and studied the composition of this biomolecular layer, which is known as protein corona. Indeed, plasma proteins adsorb on nanoparticle surface according to their abundance and affinity to the employed nanomaterial, thus even small differences between healthy and PDAC protein expression levels can be, in principle, detected. By mass spectrometry experiments, we quantified such differences and identified possible biomarkers for PDAC. Some of them are already known to exhibit different expressions in PDAC proteomes, whereas the role of other relevant proteins is still not clear. Therefore, we predict that the employment of nanomaterials and their protein corona may represent a useful tool to amplify the detection sensitivity of cancer biomarkers, which may be used for the early diagnosis of PDAC, with clinical implication for the subsequent therapy in the context of personalized medicine. Full article
(This article belongs to the Special Issue Exclusive Papers of the Editorial Board Members)
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Review

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17 pages, 727 KiB  
Review
Enhancing Antibody Exposure in the Central Nervous System: Mechanisms of Uptake, Clearance, and Strategies for Improved Brain Delivery
by Kelly Schwinghamer and Teruna J. Siahaan
J. Nanotheranostics 2023, 4(4), 463-479; https://doi.org/10.3390/jnt4040020 - 2 Oct 2023
Cited by 3 | Viewed by 3415
Abstract
Antibodies (mAbs) are attractive molecules for their application as a diagnostic and therapeutic agent for diseases of the central nervous system (CNS). mAbs can be generated to have high affinity and specificity to target molecules in the CNS. Unfortunately, only a very small [...] Read more.
Antibodies (mAbs) are attractive molecules for their application as a diagnostic and therapeutic agent for diseases of the central nervous system (CNS). mAbs can be generated to have high affinity and specificity to target molecules in the CNS. Unfortunately, only a very small number of mAbs have been specifically developed and approved for neurological indications. This is primarily attributed to their low exposure within the CNS, hindering their ability to reach and effectively engage their potential targets in the brain. This review discusses aspects of various barriers such as the blood–brain barrier (BBB) and blood–cerebrospinal fluid (CSF) barrier (BCSFB) that regulate the entry and clearance of mAbs into and from the brain. The roles of the glymphatic system on brain exposure and clearance are being described. We also discuss the proposed mechanisms of the uptake of mAbs into the brain and for clearance. Finally, several methods of enhancing the exposure of mAbs in the CNS were discussed, including receptor-mediated transcytosis, osmotic BBB opening, focused ultrasound (FUS), BBB-modulating peptides, and enhancement of mAb brain retention. Full article
(This article belongs to the Special Issue Exclusive Papers of the Editorial Board Members)
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15 pages, 1771 KiB  
Review
Recent Advances in Gold Nanomaterials for Photothermal Therapy
by Yao-Chen Chuang, Hsin-Lun Lee, Jeng-Fong Chiou and Leu-Wei Lo
J. Nanotheranostics 2022, 3(2), 117-131; https://doi.org/10.3390/jnt3020008 - 1 Jun 2022
Cited by 18 | Viewed by 5017
Abstract
Gold nanoparticle (AuNPs)-mediated photothermal therapy (PTT) has attracted increasing attention both in laboratory research and clinical applications. Due to its easily-tuned properties of irradiation light and inside-out hyperthermia ability, it has demonstrated clear advantages in cancer therapy over conventional thermal ablation. Despite this [...] Read more.
Gold nanoparticle (AuNPs)-mediated photothermal therapy (PTT) has attracted increasing attention both in laboratory research and clinical applications. Due to its easily-tuned properties of irradiation light and inside-out hyperthermia ability, it has demonstrated clear advantages in cancer therapy over conventional thermal ablation. Despite this great advancement, the therapeutic efficacy of AuNPs mediated PTT in tumor treatment remains compromised by several obstacles, including low photothermal conversion efficiency, tissue penetration limitation of excitation light, and inherent non-specificity. In view of the rapid development of AuNPs mediated PTT, we present an in-depth review of major breakthroughs in the advanced development of gold nanomaterials for PTT, with emphasis on those from 2010 to date. In particular, the current state of knowledge for AuNPs based photothermal agents within a paradigm of key structure-optical property relationships is presented in order to provide guidance for the design of novel AuNP based photothermal agents to meet necessary functional requirements in specific applications. Furthermore, potential challenges and future development of AuNP mediated PTT are also elucidated for clinical translation. It is expected that AuNP mediated PTT will soon constitute a markedly promising avenue in the treatment of cancer. Full article
(This article belongs to the Special Issue Exclusive Papers of the Editorial Board Members)
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20 pages, 5077 KiB  
Review
Implantable Devices for the Treatment of Breast Cancer
by Mohammad Mohtasim Hamid Pial, Asahi Tomitaka, Nezih Pala and Upal Roy
J. Nanotheranostics 2022, 3(1), 19-38; https://doi.org/10.3390/jnt3010003 - 9 Feb 2022
Cited by 6 | Viewed by 5627
Abstract
Breast cancer is one of the leading causes of death in the female population worldwide. Standard treatments such as chemotherapy show noticeable results. However, along with killing cancer cells, it causes systemic toxicity and apoptosis of the nearby healthy cells, therefore patients must [...] Read more.
Breast cancer is one of the leading causes of death in the female population worldwide. Standard treatments such as chemotherapy show noticeable results. However, along with killing cancer cells, it causes systemic toxicity and apoptosis of the nearby healthy cells, therefore patients must endure side effects during the treatment process. Implantable drug delivery devices that enhance therapeutic efficacy by allowing localized therapy with programmed or controlled drug release can overcome the shortcomings of conventional treatments. An implantable device can be composed of biopolymer materials, nanocomposite materials, or a combination of both. This review summarizes the recent research and current state-of-the art in these types of implantable devices and gives perspective for future directions. Full article
(This article belongs to the Special Issue Exclusive Papers of the Editorial Board Members)
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