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Advanced Studies in Marine Natural Products
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Advanced Studies in Marine Natural Products

A special issue of Journal of Marine Science and Engineering (ISSN 2077-1312). This special issue belongs to the section "Chemical Oceanography".

Deadline for manuscript submissions: closed (5 February 2023) | Viewed by 4541

Special Issue Editors

Dr. Yongxiang Song

E-Mail Website
Guest Editor
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
Interests: discovery, identification and application of bioactive natural products and enzymes from marine microorganisms
Dr. Jun Li

E-Mail Website
Guest Editor
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
Interests: the discovery; structure modification; biosynthesis of bioactive marine natural products
Dr. Le Zhou

E-Mail Website
Guest Editor
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
Interests: isolation and identification of natural products with antibacterial activity in marine microorganisms; clarify the biosynthetic pathways of microbial-derived small molecules with novel structures

Special Issue Information

Dear Colleagues,

The ocean is the source of life, which is a potential treasure for the development of new drugs. Marine life, which includes marine-derived microorganisms, plants and animals, has emerged as an important resource for bioactive natural products due to its comparable unexploited and unique living environment, such as high pressure, high salt, lack of nutrition, etc. For decades, lots of marine natural products (MNPs) with various bioactivities have been discovered and contributed to the field of biomedicine, nutraceuticals, cosmetics and agroforestry production. In order to display the contribution and potential of MNPs in improving people’s health and quality of life. We are honored to launch this Special Issue and invite the submission of research papers or reviews focused on Advanced Studies in Marine Natural Products, including the following aspects:

  • Novel and bioactive MNPs from marine life;
  • New strategies or biotechnologies for the discovery of lead compounds in marine drugs;
  • Biosynthesis of bioactive MNPs and/or their biotransformation;
  • Total synthesis and/or modification of MNPs;
  • Research and application of marine biomacromolecules.

Dr. Yongxiang Song
Dr. Jun Li
Dr. Le Zhou
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Marine Science and Engineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine natural products
  • bioactive compounds
  • biosynthesis
  • chemical synthesis/modification
  • bioengineering
  • genome mining

Published Papers (3 papers)

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Research

16 pages, 2004 KiB  
Article
Genome Sequencing of Streptomyces griseus SCSIO PteL053, the Producer of 2,2′-Bipyridine and Actinomycin Analogs, and Associated Biosynthetic Gene Cluster Analysis
by Ganesan Govindarajan, Ziwei Yao, Zhenbin Zhou, Xiaohong Zheng, Junying Ma, Pachaiyappan Saravana Kumar, Jianhua Ju and Changli Sun
J. Mar. Sci. Eng. 2023, 11(2), 396; https://doi.org/10.3390/jmse11020396 - 10 Feb 2023
Cited by 1 | Viewed by 1551
Abstract
Marine symbiotic actinomycetes play a key role in drug development and their ecological niches can influence a variety of natural product biosynthesis, providing potential defensive benefits. In this study, we report the whole-genome sequence analysis of marine gastropod mollusk Planaxis sp.-associated Streptomyces griseus [...] Read more.
Marine symbiotic actinomycetes play a key role in drug development and their ecological niches can influence a variety of natural product biosynthesis, providing potential defensive benefits. In this study, we report the whole-genome sequence analysis of marine gastropod mollusk Planaxis sp.-associated Streptomyces griseus SCSIO PteL053, which harbors 28 putative biosynthetic gene clusters (BGCs). Among them, two BGCs encoded by a hybrid non-ribosomal peptide (NRPS)/polyketide (PKS) synthetase and non-ribosomal peptide synthetase (NRPS) are responsible for the synthesis of the known therapeutic metabolites 2,2′-bipyridine and actinomycin analogs, respectively. Detailed bioinformatics analysis revealed the putative BGCs and the functions of the involved genes in the biosynthesis of the known compounds SF2738D (1), SF2738F (2), actinomycin D (3), and Actinomycin Xoβ (4). In the present study, complete-genome sequencing allowed us to rediscover known, clinically useful secondary metabolites in the newly isolated Streptomyces griseus SCSIO PteL053. Full article
(This article belongs to the Special Issue Advanced Studies in Marine Natural Products)
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6 pages, 811 KiB  
Communication
Clionaterpene, a New Cadinene Sesquiterpene from the Marine Sponge Cliona sp.
by Ying Zhou, Huixian Liang, Zhaocong Wang, Xiaojian Liao, Shihai Xu and Bingxin Zhao
J. Mar. Sci. Eng. 2023, 11(1), 131; https://doi.org/10.3390/jmse11010131 - 6 Jan 2023
Cited by 1 | Viewed by 1193
Abstract
Clionaterpene (1), a new cadinene sesquiterpene, along with six known compounds 2–7 were isolated from the marine sponge Cliona sp. The structure of 1 with absolute configuration was determined by the spectroscopic data (UV, IR, MS, and NMR) and [...] Read more.
Clionaterpene (1), a new cadinene sesquiterpene, along with six known compounds 2–7 were isolated from the marine sponge Cliona sp. The structure of 1 with absolute configuration was determined by the spectroscopic data (UV, IR, MS, and NMR) and quantum chemical calculation. Compound 1 was the first cadinene sesquiterpene metabolite isolated from this genus. In addition, the cytotoxic and antibacterial activities of these compounds were evaluated. However, none of them exhibited significant inhibition effects. Full article
(This article belongs to the Special Issue Advanced Studies in Marine Natural Products)
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14 pages, 2598 KiB  
Article
Nutritional Appraisal and Antidiabetic Activity of a Kind of Mixed Plasma Proteolytic Peptide from Tachpleus tridentatus
by Xinhuang Kang, Guoguang Zhang, Yulian Wu and Chunmei Deng
J. Mar. Sci. Eng. 2022, 10(10), 1502; https://doi.org/10.3390/jmse10101502 - 16 Oct 2022
Cited by 1 | Viewed by 1062
Abstract
Based on the bioactivities of blood protein, the nutritional appraisal and antidiabetic activity of a kind of mixed plasma proteolytic peptide from Tachpleus tridentatus (PPPT) were studied in this work. Results indicated that the amino acid level of PPPT could meet an adult’s [...] Read more.
Based on the bioactivities of blood protein, the nutritional appraisal and antidiabetic activity of a kind of mixed plasma proteolytic peptide from Tachpleus tridentatus (PPPT) were studied in this work. Results indicated that the amino acid level of PPPT could meet an adult’s FAO/WHO recommended standard; PPPT also manifested inhibitory activity on α-glucosidase with IC50 at 2.62 mg/mL in vitro, and relieved symptoms of type II diabetic mouse in vivo by improving glucose tolerance, increasing insulin secretion by 5.15 mIU/L in the PPPT-4 group and by 4.54 mIU/L in the PPPT-1 group, reducing blood glucose values to nearly normal levels 120 min after intragastric administration, and restoring pathological damage in the thymus. Thus, PPPT can be developed into both a healthcare product and an adjuvant for type II diabetes in the future. Full article
(This article belongs to the Special Issue Advanced Studies in Marine Natural Products)
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