Diagnostic Imaging: From Basic Knowledge to Latest Advancements

A special issue of Journal of Imaging (ISSN 2313-433X). This special issue belongs to the section "Medical Imaging".

Deadline for manuscript submissions: 31 August 2026 | Viewed by 3044

Editor

Special Issue Information

Dear Colleagues,

Since its birth in 1895, Diagnostic Imaging has undergone significant transformation and continues to evolve due to ongoing advancements in medical knowledge and technological equipment. The first major advancement in radiology was cross-sectional imaging, and today’s quantitative imaging technologies are enhancing the significance and clinical precision of diagnostic radiology.

In addition, advances in diagnostic imaging aid in the precise guidance of interventional procedures, from biopsies to other selected treatments.

This Special Issue aims to present a collection of high-quality articles that address all types of imaging. We aim to provide a deeper understanding of both recent advances in the field and fundamental information.

The scope of this Special Issue includes, but is not limited to, the following topics:

  • Advancements in MRI and CT applications;
  • Conventional Radiography;
  • Oncologic Imaging;
  • Musculoskeletal Imaging;
  • Imaging of rare diseases.

Dr. Paolo Spinnato
Guest Editor

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Keywords

  • magnetic resonance imaging
  • computed tomography
  • sarcoma
  • interventional radiology
  • bone and bones

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Published Papers (2 papers)

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Review

29 pages, 69011 KB  
Review
Imaging of Fibrous Dysplasia: A Comprehensive In-Depth Analysis of Monostotic, Polyostotic, Syndromic Forms, and Bone Sarcoma Development
by Paolo Spinnato, Nicola Marrone, Domenico Romeo, Matilde Gonçalves, Roberts Naglis, Leonardo Di Battista, Elena Pedrini, Maria Parisi, Raffaella Rinaldi, Silvia Gazzotti, Alberto Righi and Marco Colangeli
J. Imaging 2026, 12(6), 241; https://doi.org/10.3390/jimaging12060241 - 29 May 2026
Viewed by 711
Abstract
Fibrous dysplasia is one of the most common skeletal lesions. The wide spectrum of clinical manifestations ranges from asymptomatic conditions (typical of monostotic forms) to severe skeletal diseases with deformity and fractures for polyostotic fibrous dysplasia. The classical radiological features include: an osteolytic [...] Read more.
Fibrous dysplasia is one of the most common skeletal lesions. The wide spectrum of clinical manifestations ranges from asymptomatic conditions (typical of monostotic forms) to severe skeletal diseases with deformity and fractures for polyostotic fibrous dysplasia. The classical radiological features include: an osteolytic geographic pattern, ground-glass bone matrix, cortical thinning/cortical scalloping, bone deformities and enlargement, concavity of margins (evaluated with MRI), and cystic areas (MRI). All the bones can be affected, and the proximal femur is the most common one (about 30% of cases). Nonetheless, the disease can also affect cranio-facial bones, leading to compression of neural structures, as well as deformation and enlargement of facial bones, leading to the so-called “leontiasis ossea” or “facies leonine”. The polyostotic forms of fibrous dysplasia can be associated with multiple soft-tissue myomas (Mazabraud syndrome) or several endocrine diseases (McCune–Albright syndrome). In every diagnostic step of the disease, as well as in different fibrous dysplasia forms, imaging plays a key role. Indeed, radiology is fundamental to assess the suspicion of fibrous dysplasia in classical monostotic forms, representing the sole diagnostic tool needed in many cases. Imaging is also fundamental to staging and following up on more severe polyostotic forms, as well as for detecting complications. In this comprehensive updated review article, we examine every aspect of the disease, with a main focus on imaging presentation. The indications for biopsy are discussed as well. Most importantly, the article details the potential risk of malignant transformation (osteosarcoma, fibrosarcoma, chondrosarcoma, and other rarer sarcomas, all accounting for <1% of cases) underlying the radiological patterns of these conditions. The occurrence of aneurysmal bone cyst-like changes on fibrous dysplasia is also analyzed in the article. This review article aims to be a comprehensive guide for radiologists and clinicians involved in the care of patients affected by various forms of fibrous dysplasia, and a starting point for future research. Many classical and atypical cases are collected as an iconographic comprehensive representation. Full article
(This article belongs to the Special Issue Diagnostic Imaging: From Basic Knowledge to Latest Advancements)
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16 pages, 601 KB  
Review
The Retina as a Proxy for Brain Neurodegeneration: A Narrative Review on OCT-Based Retinal Imaging in the Early Detection of Alzheimer’s and Parkinson’s Disease
by Ouafa Sijilmassi
J. Imaging 2026, 12(3), 104; https://doi.org/10.3390/jimaging12030104 - 27 Feb 2026
Viewed by 1890
Abstract
Neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD), are major causes of cognitive and motor decline, yet early diagnosis remains challenging due to asymptomatic phases and limited non-invasive biomarkers. This narrative review systematically synthesized studies on retinal imaging in AD and [...] Read more.
Neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD), are major causes of cognitive and motor decline, yet early diagnosis remains challenging due to asymptomatic phases and limited non-invasive biomarkers. This narrative review systematically synthesized studies on retinal imaging in AD and PD. Published studies were identified through searches of PubMed, MEDLINE, Google Scholar, and reference lists, focusing on Optical Coherence Tomography (OCT), OCT Angiography (OCTA), and Spectral-Domain OCT (SD-OCT) assessing retinal structural and vascular changes. Data were extracted on retinal layer thickness, vascular parameters, and diagnostic metrics. Findings indicate that both diseases consistently exhibit thinning of inner retinal layers, particularly the retinal nerve fiber layer (RNFL) and ganglion cell–inner plexiform layer (GCIPL). In AD, studies reported progressive inner retinal thinning across disease stages, sometimes accompanied by outer retinal and retinal pigment epithelium changes. In PD, thinning was observed predominantly in RNFL and GCIPL, correlating with disease duration and motor severity. Microvascular alterations were described in both disorders, with disease-specific spatial patterns reported across studies. Overall, retinal imaging emerges as a non-invasive, high-resolution, and cost-effective tool for early detection, differential assessment, and longitudinal monitoring of neurodegenerative diseases. These findings support the translation of retinal biomarkers into clinical practice for improved disease management. Full article
(This article belongs to the Special Issue Diagnostic Imaging: From Basic Knowledge to Latest Advancements)
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