Nanoengineered Materials for Biomedical Applications

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983).

Deadline for manuscript submissions: closed (20 April 2023) | Viewed by 13158

Special Issue Editor

Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA
Interests: nano(bio)technology; nanomedicine; biomaterials; tissue engineering; cardiovascular regenerative medicine; stem cells; 3D bioprinting; wound healing; drug delivery; antimicrobial materials; hydrogels; electrospun scaffolds; materials science and engineering
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Special Issue Information

Dear Colleagues,

The nanoscale is the scale at which surfaces and interfaces play a vital role in a material’s properties and interactions. Nanoscale materials have far larger surface areas than similar masses of larger-scale materials, which significantly increases their reactivity. The emergence of nanotechnology has set high expectations for addressing the complexities and difficulties in medicine and biological sciences such as cardiovascular disease, cancer, neuronal disorders, vascularization, bone, skin and muscle disorders, etc. Moreover, nanotechnological advances have improved the safety and efficacy of diagnostic, therapeutic, and theranostic approaches for various diseases. Surfaces, structures, and biomaterials with nanoscale features not only can trigger select cell migration, adhesion, growth, proliferation, and differentiation but also have the potential to mimic the natural micro-nano environment of cells due to the close relationship between biological systems and nanoscale features. Nanoengineered materials can also provide novel solutions by developing desirable and ideal materials to control the physicochemical, biological, structural, and mechanical microenvironment for successful cell delivery and tissue regeneration.

It is our pleasure to invite you to submit a manuscript (full research papers, review articles, opinions, and communications) for this Special Issue focusing on nanoengineered biomaterials, including but not limited to nanoparticles, self-assembled nanomaterials, nanotubes, nanotopographies, functionalized nanomaterials, nanofibrous scaffolds, nanocomposites, hydrogels, 3D printed constructs, etc., for different biomedical applications.

Dr. Ebrahim Mostafavi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanotechnology
  • nanomaterials
  • biomaterials
  • nanoparticles
  • cells
  • nano-bio interfaces

Published Papers (3 papers)

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Research

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14 pages, 7533 KiB  
Article
Direct Ink Write Printing of Chitin-Based Gel Fibers with Customizable Fibril Alignment, Porosity, and Mechanical Properties for Biomedical Applications
by Devis Montroni, Takeru Kobayashi, Taige Hao, Derek Lublin, Tomoko Yoshino and David Kisailus
J. Funct. Biomater. 2022, 13(2), 83; https://doi.org/10.3390/jfb13020083 - 16 Jun 2022
Cited by 4 | Viewed by 2386
Abstract
A fine control over different dimensional scales is a challenging target for material science since it could grant control over many properties of the final material. In this study, we developed a multivariable additive manufacturing process, direct ink write printing, to control different [...] Read more.
A fine control over different dimensional scales is a challenging target for material science since it could grant control over many properties of the final material. In this study, we developed a multivariable additive manufacturing process, direct ink write printing, to control different architectural features from the nano- to the millimeter scale during extrusion. Chitin-based gel fibers with a water content of around 1500% were obtained extruding a polymeric solution of chitin into a counter solvent, water, inducing instant solidification of the material. A certain degree of fibrillar alignment was achieved basing on the shear stress induced by the nozzle. In this study we took into account a single variable, the nozzle’s internal diameter (NID). In fact, a positive correlation between NID, fibril alignment, and mechanical resistance was observed. A negative correlation with NID was observed with porosity, exposed surface, and lightly with water content. No correlation was observed with maximum elongation (~50%), and the scaffold’s excellent biocompatibility, which appeared unaltered. Overall, a single variable allowed a customization of different material features, which could be further tuned, adding control over other aspects of the synthetic process. Moreover, this manufacturing could be potentially applied to any polymer. Full article
(This article belongs to the Special Issue Nanoengineered Materials for Biomedical Applications)
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12 pages, 3215 KiB  
Article
In Vitro Corrosion of SiC-Coated Anodized Ti Nano-Tubular Surfaces
by Shu-Min Hsu, Chaker Fares, Xinyi Xia, Md Abu Jafar Rasel, Jacob Ketter, Samira Esteves Afonso Camargo, Md Amanul Haque, Fan Ren and Josephine F. Esquivel-Upshaw
J. Funct. Biomater. 2021, 12(3), 52; https://doi.org/10.3390/jfb12030052 - 16 Sep 2021
Cited by 2 | Viewed by 3149
Abstract
Peri-implantitis leads to implant failure and decreases long-term survival and success rates of implant-supported prostheses. The pathogenesis of this disease is complex but implant corrosion is believed to be one of the many factors which contributes to progression of this disease. A nanostructured [...] Read more.
Peri-implantitis leads to implant failure and decreases long-term survival and success rates of implant-supported prostheses. The pathogenesis of this disease is complex but implant corrosion is believed to be one of the many factors which contributes to progression of this disease. A nanostructured titanium dioxide layer was introduced using anodization to improve the functionality of dental implants. In the present study, we evaluated the corrosion performance of silicon carbide (SiC) on anodized titanium dioxide nanotubes (ATO) using plasma-enhanced chemical vapor deposition (PECVD). This was investigated through a potentiodynamic polarization test and bacterial incubation for 30 days. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) were used to analyze surface morphologies of non-coated and SiC-coated nanotubes. Energy dispersive X-ray (EDX) was used to analyze the surface composition. In conclusion, SiC-coated ATO exhibited improved corrosion resistance and holds promise as an implant coating material. Full article
(This article belongs to the Special Issue Nanoengineered Materials for Biomedical Applications)
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Review

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35 pages, 8178 KiB  
Review
Two-Dimensional Nanomaterials beyond Graphene for Biomedical Applications
by Maryam Derakhshi, Sahar Daemi, Pegah Shahini, Afagh Habibzadeh, Ebrahim Mostafavi and Ali Akbar Ashkarran
J. Funct. Biomater. 2022, 13(1), 27; https://doi.org/10.3390/jfb13010027 - 09 Mar 2022
Cited by 47 | Viewed by 5741
Abstract
Two-dimensional (2D) nanomaterials (e.g., graphene) have shown to have a high potential in future biomedical applications due to their unique physicochemical properties such as unusual electrical conductivity, high biocompatibility, large surface area, and extraordinary thermal and mechanical properties. Although the potential of graphene [...] Read more.
Two-dimensional (2D) nanomaterials (e.g., graphene) have shown to have a high potential in future biomedical applications due to their unique physicochemical properties such as unusual electrical conductivity, high biocompatibility, large surface area, and extraordinary thermal and mechanical properties. Although the potential of graphene as the most common 2D nanomaterials in biomedical applications has been extensively investigated, the practical use of other nanoengineered 2D materials beyond graphene such as transition metal dichalcogenides (TMDs), topological insulators (TIs), phosphorene, antimonene, bismuthene, metal–organic frameworks (MOFs) and MXenes for biomedical applications have not been appreciated so far. This review highlights not only the unique opportunities of 2D nanomaterials beyond graphene in various biomedical research areas such as bioelectronics, imaging, drug delivery, tissue engineering, and regenerative medicine but also addresses the risk factors and challenges ahead from the medical perspective and clinical translation of nanoengineered 2D materials. In conclusion, the perspectives and future roadmap of nanoengineered 2D materials beyond graphene are outlined for biomedical applications. Full article
(This article belongs to the Special Issue Nanoengineered Materials for Biomedical Applications)
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