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Advances in Injectable Biomaterials
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Advances in Injectable Biomaterials

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983).

Deadline for manuscript submissions: closed (31 December 2011) | Viewed by 8516

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Prof. Dr. Jons Hilborn

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Department of Materials Chemistry, Uppsala University, Box 538, SE-751 21 Uppsala, Sweden

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Research

10 pages, 567 KiB  
Article
Sustained Delivery of Chondroitinase ABC from Hydrogel System
by Filippo Rossi, Pietro Veglianese, Marco Santoro, Simonetta Papa, Cristina Rogora, Valentina Dell’Oro, Gianluigi Forloni, Maurizio Masi and Giuseppe Perale
J. Funct. Biomater. 2012, 3(1), 199-208; https://doi.org/10.3390/jfb3010199 - 19 Mar 2012
Cited by 13 | Viewed by 8145
Abstract
In the injured spinal cord, chondroitin sulfate proteoglycans (CSPGs) are the principal responsible of axon growth inhibition and they contribute to regenerative failure, promoting glial scar formation. Chondroitinase ABC (chABC) is known for being able to digest proteoglycans, thus degrading glial scar and [...] Read more.
In the injured spinal cord, chondroitin sulfate proteoglycans (CSPGs) are the principal responsible of axon growth inhibition and they contribute to regenerative failure, promoting glial scar formation. Chondroitinase ABC (chABC) is known for being able to digest proteoglycans, thus degrading glial scar and favoring axonal regrowth. However, its classic administration is invasive, infection-prone and clinically problematic. An agarose-carbomer (AC1) hydrogel, already used in SCI repair strategies, was here investigated as a delivery system capable of an effective chABC administration: the material ability to include chABC within its pores and the possibility to be injected into the target tissue were firstly proved. Subsequently, release kinetic and the maintenance of enzymatic activity were positively assessed: AC1 hydrogel was thus confirmed to be a feasible tool for chABC delivery and a promising device for spinal cord injury topic repair strategies. Full article
(This article belongs to the Special Issue Advances in Injectable Biomaterials)
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