Next Article in Journal
Finite-Element Modeling of Viscoelastic Cells During High-Frequency Cyclic Strain
Previous Article in Journal
Experimental Models for Investigating Intra-Stromal Migration of Corneal Keratocytes, Fibroblasts and Myofibroblasts
Open AccessArticle

Sustained Delivery of Chondroitinase ABC from Hydrogel System

1
Department of Chemistry, Materials and Chemical Engineering “Giulio Natta”, Politecnico di Milano, via Mancinelli 7, Milan 20131, Italy
2
Department of Neuroscience, Mario Negri Institute for Pharmacological Research, via La Masa 19, Milan 20156, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
J. Funct. Biomater. 2012, 3(1), 199-208; https://doi.org/10.3390/jfb3010199
Received: 19 December 2011 / Revised: 27 February 2012 / Accepted: 13 March 2012 / Published: 19 March 2012
(This article belongs to the Special Issue Advances in Injectable Biomaterials)
In the injured spinal cord, chondroitin sulfate proteoglycans (CSPGs) are the principal responsible of axon growth inhibition and they contribute to regenerative failure, promoting glial scar formation. Chondroitinase ABC (chABC) is known for being able to digest proteoglycans, thus degrading glial scar and favoring axonal regrowth. However, its classic administration is invasive, infection-prone and clinically problematic. An agarose-carbomer (AC1) hydrogel, already used in SCI repair strategies, was here investigated as a delivery system capable of an effective chABC administration: the material ability to include chABC within its pores and the possibility to be injected into the target tissue were firstly proved. Subsequently, release kinetic and the maintenance of enzymatic activity were positively assessed: AC1 hydrogel was thus confirmed to be a feasible tool for chABC delivery and a promising device for spinal cord injury topic repair strategies. View Full-Text
Keywords: chondroitinase ABC; hydrogels; drug delivery; spinal cord injury chondroitinase ABC; hydrogels; drug delivery; spinal cord injury
Show Figures

Graphical abstract

MDPI and ACS Style

Rossi, F.; Veglianese, P.; Santoro, M.; Papa, S.; Rogora, C.; Dell’Oro, V.; Forloni, G.; Masi, M.; Perale, G. Sustained Delivery of Chondroitinase ABC from Hydrogel System. J. Funct. Biomater. 2012, 3, 199-208.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop