Dear Colleagues,

By definition, a biomaterial is ‘a material designed to take a form that can direct, through interaction with living systems, the course of any therapeutic or diagnostic procedure. This may appear to be a rather general definition, but it contains a number of subtle complexities. These largely relate to the details of interactions with living systems, which primarily encompass phenomena of biocompatibility and bioactivity.

In addition, it is clear that the concept of a biomaterial necessarily entails clinical procedures, specifically therapeutic or diagnostic procedures.  The real significance of these factors is that we cannot consider biomaterials as simple structures that are placed passively in the body where they are treated as foreign bodies, with variable and predictable consequences. Biomaterials, in current clinical applications, have to be functional and have to have controlled interactivity with the tissues and organs with which they are in contact. 

This Special Issue covers some of the critical aspects of clinical biocompatibility and bioactivity phenomena, especially as they relate to advanced functional biomaterials.

Prof. Dr. David F. Williams
Guest Editor

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• Biocompatibility
• Bioactivity
• Dental
• Stem cells
• Biomaterials
• Implants
• Scaffolds
• Clinical