Special Issue "Blood Substitutes: Evolution and Future Applications"
A special issue of Journal of Functional Biomaterials (ISSN 2079-4983).
Deadline for manuscript submissions: closed (3 July 2017)
Prof. Dr. Hiromi Sakai
Department of Chemistry, Nara Medical University, Shijo-cho 840, Kashihara, Nara 634-8521, Japan
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Interests: artificial oxygen carriers; molecular assembly; liposome; redox and ligand binding of hemoglobin; tissue oxygenation; tissue engineering; microvascular physiology; hemorheology; microhemodynamics
Hemoglobin (Hb) functions as an oxygen-binding protein in blood. The fact that Hb is the most abundant protein in blood reflects that oxygen transport is the most important function of blood to maintain vital activity. Nevertheless, Hb shows cardiovascular, renal, and neurological toxicity once it is released from erythrocytes. When Hb is used as a biomaterial and as a source of making artificial oxygen carriers (blood substitutes), it is necessary to purify Hb extensively to eliminate pathogens, to engineer Hb with chemical modification, bioconjugation, encapsulation or recombinant technology, to eliminate such toxic effects of molecular Hb, and to prepare a fluid with important physicochemical properties such as affinities to endogenous gas molecules, particle size, osmotic pressure, and viscosity to mimic the characteristics of blood. The advantages of artificial oxygen carriers (blood substitutes) are that they have no contamination of pathogens or blood type antigen, and that they have sufficient stability for long-term stockpiling. They were developed originally as a transfusion alternative. However, their different physicochemical properties from those of erythrocytes enable other clinical applications that include the following: oxygen therapeutics for ischemic diseases, cancer, inflammatory disease, and sickle cell disease; and perfusates for transplantation, tissue engineering, and other applications. They are also used as carbon monoxide carriers to prevent diseases related to oxidative stress. Consequently, the research field of blood substitutes continues to expand.
This Special Issue, “Blood Substitutes: Evolution and Future Application”, provides a multidisciplinary forum for original research articles as well as critical reviews and perspectives related to current advances and innovations in the field of blood substitutes from academia and industry.
Prof. Dr. Hiromi Sakai
Manuscript Submission Information
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- Design, synthesis, and physicochemical properties of artificial oxygen carriers and fluids
- Toxicity of Hb and its mechanisms
- Purification processes for Hb
- Safety and efficacy of blood substitutes
- Impact on microhemodynamics by injection of artificial oxygen carriers
- Design of preclinical and clinical studies
- Transfusion alternatives, oxygen therapeutics, CO therapeutics, photosensitizers, and other potential clinical applications