3D Printing Biomaterials and Technologies in Biomedical Applications

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Synthesis of Biomaterials via Advanced Technologies".

Deadline for manuscript submissions: closed (28 February 2026) | Viewed by 1332

Special Issue Editor


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Guest Editor
School of Mechanical and Power Engineering, East China University of Science and Technology, Shanghai 200237, China
Interests: 3D bioprinting; bio-inks; bionic scaffolds
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Special Issue Information

Dear Colleagues,

This Special Issue focuses on recent advances in 3D printing biomaterials and technologies for biomedical applications. The 3D printing technique has developed rapidly, including micro-extrusion bioprinting, inkjet bioprinting, laser-assisted bioprinting, and scaffold-free spheroid-based bioprinting, which offers great promise in the fields of regenerative medicine and drug delivery. At the same time, novel biomaterials designed for 3D printing have been developed, such as hydrogels, composites, and biodegradable polymers. These materials are tailored to meet the specific mechanical, biological, and chemical properties required for medical applications, including implants and prosthetics. This Special Issue seeks to publish work on various bio-fabrication technologies in medical applications, including, but not limited to, 3D printing and bioprinting biomaterials, bio-chip, organ-on-a-chip, organoid, implants, medical devices, and surgical simulation tools. Both original research articles and reviews are welcome as part of this Special Issue.

Prof. Dr. Hongbo Zhang
Guest Editor

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Keywords

  • 3D printing
  • in vitro models
  • organoids and oeganoids-on-chip
  • orgaon-on-a-chip
  • 4D bioprinting
  • tissue engineering
  • biomaterials

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Published Papers (1 paper)

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Research

16 pages, 2393 KB  
Article
Parameter Optimisation in 3D Extrusion Printing of Polyhydroxybutyrate Using Design of Experiment Methodology
by Mingzu Du, Giuseppe Tronci, Xuebin B. Yang and David J. Wood
J. Funct. Biomater. 2026, 17(2), 90; https://doi.org/10.3390/jfb17020090 - 12 Feb 2026
Viewed by 888
Abstract
This study systematically optimised extrusion-printing parameters for polyhydroxybutyrate (PHB) using a Design of Experiment (DoE) approach to improve printability and construct fidelity. A five-factor DoE was conducted to evaluate the individual and interactive effects of printhead temperature, printing pressure, printing speed, bed temperature, [...] Read more.
This study systematically optimised extrusion-printing parameters for polyhydroxybutyrate (PHB) using a Design of Experiment (DoE) approach to improve printability and construct fidelity. A five-factor DoE was conducted to evaluate the individual and interactive effects of printhead temperature, printing pressure, printing speed, bed temperature, and cartridge heating time on the dimensional accuracy of printed constructs. The resulting regression model enabled the identification of statistically significant main and interaction effects among processing variables. An optimised parameter set (printhead temperature 145 °C, pressure 150 kPa, speed 15 mm s−1, bed temperature 25 °C, and cartridge heating time 120 s) enabled the fabrication of PHB scaffolds with substantially improved shape fidelity, which was experimentally validated using verification prints. These results demonstrate that a DoE-based optimisation strategy provides a robust and efficient route for rationally tuning PHB extrusion-printing conditions, thereby enhancing process reliability for scaffold fabrication in regenerative medicine applications. Full article
(This article belongs to the Special Issue 3D Printing Biomaterials and Technologies in Biomedical Applications)
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