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Antibacterial Biomaterials
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Antibacterial Biomaterials

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Antibacterial Biomaterials".

Deadline for manuscript submissions: closed (10 April 2023) | Viewed by 10571

Special Issue Editor

Dr. Laurent Pieuchot

E-Mail Website
Guest Editor
Institut de Science des Matériaux de Mulhouse, Université de Haute-Alsace, 68057 Mulhouse, France
Interests: biomaterials; antimicrobial agents; functional zeolites; surface functionalization; mechanobiology; cell migration; tissue morphogenesis

Special Issue Information

Dear Colleagues,

Microbial infections on biomaterials or implanted devices can lead to severe postoperative complications, and are therefore a prominent concern in the healthcare industry. For example, biofilm formation can strongly compromise the wound-healing process, device integration, and lead to the emergence of antibiotic resistance. Recent advances have been made to implement antimicrobial properties in the design of biomaterials in order to overcome these infection-related complications. Various techniques have been developed to modify the surface chemistry or topography, or to associate antimicrobial components such as metallic ions, natural extracts, or peptides that can be released over time and confer long-term antimicrobial properties. The goal of this Special Issue is to compile recent advances in antimicrobial biomaterial design and give a focused overview on new and trending research in the field.

Dr. Laurent Pieuchot
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial agents
  • silver ion
  • metal-exchanged zeolite
  • polymer engineering
  • polymer synthesis
  • surface functionalization
  • antimicrobial peptide
  • antimicrobial agents immobilization
  • bactericidal additives
  • antimicrobial agents diffusion
  • new drug delivery systems
  • microbiocidal
  • infection control

Published Papers (5 papers)

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Research

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17 pages, 2913 KiB  
Article
Antimicrobial Effect of the Amniotic Membrane Isolated and Associated with Photodynamic Therapy
by Amanda Cerquearo Rodrigues dos Santos, Guilherme Rodrigues Teodoro, Juliana Ferreira-Strixino and Luciana Barros Sant’Anna
J. Funct. Biomater. 2023, 14(3), 151; https://doi.org/10.3390/jfb14030151 - 08 Mar 2023
Viewed by 1474
Abstract
Microbial control through alternative therapies, such as the amniotic membrane (AM) and antimicrobial photodynamic therapy (aPDT), has been gaining prominence with the advancement of bacterial resistance to conventional treatments. This study aimed to evaluate the antimicrobial effect of AM isolated and associated with [...] Read more.
Microbial control through alternative therapies, such as the amniotic membrane (AM) and antimicrobial photodynamic therapy (aPDT), has been gaining prominence with the advancement of bacterial resistance to conventional treatments. This study aimed to evaluate the antimicrobial effect of AM isolated and associated with aPDT using the PHTALOX® as a photosensitizer (PS) against Staphylococcus aureus and Pseudomonas aeruginosa biofilms. The groups studied were: C+; L; AM; AM+L; AM+PHTX; and AM+aPDT. The irradiation parameters were 660 nm, 50 J.cm−2, and 30 mW.cm−2. Two independent microbiological experiments were carried out in triplicate, and the results were analyzed by CFU/mL counting and a metabolic activity test, both statistically analyzed (p < 0.05). The integrity of the AM was verified after the treatments by a scanning electron microscope (SEM). The groups AM, AM+PHTX, and, mainly, AM+aPDT showed a statistical difference when compared to C+ regarding the decrease in CFU/mL and metabolic activity. SEM analysis showed significant morphological alterations in the AM+PHTX and AM+aPDT groups. The treatments with AM isolated or associated with PHTALOX® were adequate. The association had potentiated the biofilm effect, and the morphological differences presented by AM after treatment did not hinder its antimicrobial effect, encouraging its use in biofilm formation locals. Full article
(This article belongs to the Special Issue Antibacterial Biomaterials)
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11 pages, 255 KiB  
Article
Meropenem/Vaborbactam and Cefiderocol as Combination or Monotherapy to Treat Multi-Drug Resistant Gram-Negative Infections: A Regional Cross-Sectional Survey from Piedmont Infectious Disease Unit Network (PIDUN)
by Tommaso Lupia, Silvia Corcione, Nour Shbaklo, Giorgia Montrucchio, Ilaria De Benedetto, Valentina Fornari, Roberta Bosio, Barbara Rizzello, Simone Mornese Pinna, Luca Brazzi and Francesco Giuseppe De Rosa
J. Funct. Biomater. 2022, 13(4), 174; https://doi.org/10.3390/jfb13040174 - 03 Oct 2022
Cited by 4 | Viewed by 1589
Abstract
Meropenem/vaborbactam (MV) and cefiderocol were recently approved by the Food and Drug Administration and European Medicines Agency and are among the most promising antibacterial in treatment regimens against multi-drug resistant (MDR) gram-negative bacilli. A survey with close-ended questions was proposed to infectious disease [...] Read more.
Meropenem/vaborbactam (MV) and cefiderocol were recently approved by the Food and Drug Administration and European Medicines Agency and are among the most promising antibacterial in treatment regimens against multi-drug resistant (MDR) gram-negative bacilli. A survey with close-ended questions was proposed to infectious disease (ID) and intensive care unit (ICU) physicians of Piedmont and Valle d’Aosta Region’s hospitals. The aim was to collect data about habits and prescriptions of cefiderocol and MV. Twenty-three physicians (11 ID specialists and 12 anesthesiologists) in 13 Italian hospitals took part in the survey. Both cefiderocol and MV were mostly used as target therapy after a previous treatment failure and after ID specialist consult. The most frequent MDR pathogen in hospitals was Klebsiella pneumoniae carbapenemase-producing bacteria (KPC), followed by P. aeruginosa and A. baumannii. MDRs were more frequently isolated in ICU. In conclusion, cefiderocol was used in empiric regimens when A. baumannii was suspected, while MV was more used in suspect of KPC. MV and cefiderocol can be the first option in empiric treatment for critically ill patients in settings with high risk of MDR. The treatment should then be followed by rapid de-escalation when microbiological results are available. Full article
(This article belongs to the Special Issue Antibacterial Biomaterials)
14 pages, 9434 KiB  
Article
Cu2+ Release from Polylactic Acid Coating on Titanium Reduces Bone Implant-Related Infection
by Chengdong Zhang, Xingping Li, Dongqin Xiao, Qiao Zhao, Shuo Chen, Fei Yang, Jinhui Liu and Ke Duan
J. Funct. Biomater. 2022, 13(2), 78; https://doi.org/10.3390/jfb13020078 - 10 Jun 2022
Cited by 5 | Viewed by 2100
Abstract
Implant-related infection (IRI) is a major problem in orthopedics. Copper (Cu) is an essential trace element with strong bactericidal activity and, thus, presents potential for reducing IRI. The present study explored a straightforward strategy for releasing Cu2+ from titanium (Ti) implants, and [...] Read more.
Implant-related infection (IRI) is a major problem in orthopedics. Copper (Cu) is an essential trace element with strong bactericidal activity and, thus, presents potential for reducing IRI. The present study explored a straightforward strategy for releasing Cu2+ from titanium (Ti) implants, and we conducted a preliminary study to assess the feasibility of this approach in clinical translation. Polylactic acid (PLA) coatings containing different concentrations of copper ions were prepared on Ti discs. The antibacterial activity and biocompatibility of the copper ion-incorporated Ti implants were evaluated using Staphylococcus aureus (S. aureus), bone marrow mesenchymal stem cells (BMSCs) and animal models. In vitro, the coatings produced burst release of Cu2+ in 12 h, and inhibited S. aureus growth in a dose-dependent manner. The coatings prepared from PLA solutions containing 0.5 or 1.0 mg/mL reduced the viability and osteogenic differentiation of BMSCs, but these effects were negated after the coatings were immersed in culture medium for 6 h. Four weeks after implantation, the Cu-free K-wires challenged with S. aureus had persistent infection and inferior fracture healing to the other three groups, while Cu-coated wires had no evidence of infection. Furthermore, the Cu-coated wires placed in rabbits without S. aureus challenge showed superior fracture healing to the other three groups. These results suggest that PLA coatings containing Cu2+ may be an effective design for reducing IRI without adversely affecting adjacent bone healing. Full article
(This article belongs to the Special Issue Antibacterial Biomaterials)
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15 pages, 2990 KiB  
Article
Rational Design and Characterisation of Novel Mono- and Bimetallic Antibacterial Linde Type A Zeolite Materials
by Emmanuel Oheix, Chloé Reicher, Habiba Nouali, Laure Michelin, Ludovic Josien, T. Jean Daou and Laurent Pieuchot
J. Funct. Biomater. 2022, 13(2), 73; https://doi.org/10.3390/jfb13020073 - 02 Jun 2022
Cited by 3 | Viewed by 2435
Abstract
The development of antimicrobial devices and surfaces requires the setup of suitable materials, able to store and release active principles. In this context, zeolites, which are microporous aluminosilicate minerals, hold great promise, since they are able to serve as a reservoir for metal-ions [...] Read more.
The development of antimicrobial devices and surfaces requires the setup of suitable materials, able to store and release active principles. In this context, zeolites, which are microporous aluminosilicate minerals, hold great promise, since they are able to serve as a reservoir for metal-ions with antimicrobial properties. Here, we report on the preparation of Linde Type A zeolites, partially exchanged with combinations of metal-ions (Ag+, Cu2+, Zn2+) at different loadings (0.1–11.9 wt.%). We combine X-ray fluorescence, scanning electron microscopy, energy-dispersive X-ray spectroscopy, and X-ray diffraction to monitor the metal-ion contents, distribution, and conservation of the zeolite structure after exchange. Then, we evaluate their antimicrobial activity, using agar dilution and optical-density monitoring of Escherichia coli cultures. The results indicate that silver-loaded materials are at least 70-fold more active than the copper-, zinc-, and non-exchanged ones. Moreover, zeolites loaded with lower Ag+ concentrations remain active down to 0.1 wt.%, and their activities are directly proportional to the total Ag content. Sequential exchanges with two metal ions (Ag+ and either Cu2+, Zn2+) display synergetic or antagonist effects, depending on the quantity of the second metal. Altogether, this work shows that, by combining analytical and quantitative methods, it is possible to fine-tune the composition of bi-metal-exchanged zeolites, in order to maximise their antimicrobial potential, opening new ways for the development of next-generation composite zeolite-containing antimicrobial materials, with potential applications for the design of dental or bone implants, as well as biomedical devices and pharmaceutical products. Full article
(This article belongs to the Special Issue Antibacterial Biomaterials)
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Review

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20 pages, 2775 KiB  
Review
Antibacterial Adhesion Strategy for Dental Titanium Implant Surfaces: From Mechanisms to Application
by Jingwei Yu, Minghao Zhou, Luxuan Zhang and Hongbo Wei
J. Funct. Biomater. 2022, 13(4), 169; https://doi.org/10.3390/jfb13040169 - 29 Sep 2022
Cited by 8 | Viewed by 2392
Abstract
Dental implants are widely used to restore missing teeth because of their stability and comfort characteristics. Peri-implant infection may lead to implant failure and other profound consequences. It is believed that peri-implantitis is closely related to the formation of biofilms, which are difficult [...] Read more.
Dental implants are widely used to restore missing teeth because of their stability and comfort characteristics. Peri-implant infection may lead to implant failure and other profound consequences. It is believed that peri-implantitis is closely related to the formation of biofilms, which are difficult to remove once formed. Therefore, endowing titanium implants with anti-adhesion properties is an effective method to prevent peri-implant infection. Moreover, anti-adhesion strategies for titanium implant surfaces are critical steps for resisting bacterial adherence. This article reviews the process of bacterial adhesion, the material properties that may affect the process, and the anti-adhesion strategies that have been proven effective and promising in practice. This article intends to be a reference for further improvement of the antibacterial adhesion strategy in clinical application and for related research on titanium implant surfaces. Full article
(This article belongs to the Special Issue Antibacterial Biomaterials)
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