Development of Biocomposites for Bone Tissue Engineering

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Bone Biomaterials".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 4370

Special Issue Editors


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Guest Editor
i3S-Institute for Research and Innovation in Health and Faculty of Medicine, University of Porto, Porto, Portugal
Interests: osteomyelitis; hydroxyapatite; drug-delivering materials

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Guest Editor
1. i3S—Institute for Research and Innovation in Health, University of Porto, 4200-135 Porto, Portugal
2. Department of Metallurgical and Materials Engineering, Faculty of Engineering, University of Porto, 4200-465 Porto, Portugal
Interests: biomaterials; drug delivery systems; anti-microbial resistance; bone scaffolds; bone infection
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Special Issue Information

Dear Colleagues,

This Special Issue will focus on recent advances in the development, characterization, and application of biocomposites for bone tissue engineering. Emphasis will be placed on materials that combine bioactivity, biocompatibility, and appropriate mechanical properties to support bone regeneration. This issue welcomes original research, reviews, and translational studies that explore ceramic–polymer composites, natural biomaterials, scaffold fabrication techniques, functionalization strategies, and biological performance both in vitro and in vivo.

The aim is to provide a comprehensive overview of the state of the art in this rapidly evolving field, highlighting innovations that bridge the gap between fundamental research and clinical application. Contributions spanning materials science, bioengineering, and regenerative medicine are particularly encouraged.

In the context of the existing literature, this Special Issue seeks to integrate diverse material strategies and fabrication technologies that are often addressed in isolation. By bringing these areas together, it will offer a multidisciplinary perspective on composite systems designed specifically for bone repair. This focused collection will serve as a valuable reference for researchers and clinicians, identifying current challenges, future directions, and opportunities for innovation in the development of biocomposites for skeletal tissue engineering.

Prof. Dr. Nuno Alegrete
Prof. Dr. Maria Pia Ferraz
Guest Editors

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Keywords

  • biocomposites
  • bone tissue engineering
  • biodegradable polymers
  • bioactive ceramics
  • scaffold fabrication
  • osteogenesis
  • regenerative biomaterials

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Published Papers (1 paper)

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Research

16 pages, 10391 KB  
Article
Synergistic Effect of Conditioned Medium and Calcium Phosphate Biocement on Osteogenic Properties of Composite
by Mária Giretová, Ľubomír Medvecký, Lenka Luptáková, Radoslava Štulajterová, Tibor Sopčák and Eva Székiová
J. Funct. Biomater. 2026, 17(1), 10; https://doi.org/10.3390/jfb17010010 - 22 Dec 2025
Viewed by 412
Abstract
The aim of the study was to investigate the synergistic effect of conditioned medium (CM) and two types of calcium phosphate biocements on the osteogenic properties of a composite material through rat bone marrow-derived mesenchymal stem cells (MSCs). Briefly, MSCs were cultured for [...] Read more.
The aim of the study was to investigate the synergistic effect of conditioned medium (CM) and two types of calcium phosphate biocements on the osteogenic properties of a composite material through rat bone marrow-derived mesenchymal stem cells (MSCs). Briefly, MSCs were cultured for 7 and 17 days in extracts derived from the two biocement types. These extracts were supplemented with 5% (v/v) of concentrated CM. The CM was obtained from rat bone marrow MSC cultures after a 48 h conditioning period. The results showed that the addition of CM had a significant positive impact on the osteoblastic differentiation of MSCs, particularly in the extracts from the tetracalcium phosphate/monetite/calcium sulfate hemihydrate biocement (designated as CAS cement) compared to the other tested cement extract (designated C cement). After 17 days of culturing, a notable increase in cell viability and alkaline phosphatase (ALP) activity, as well as the upregulation of osteoblastic-related gene expression, was found. This enhancement in osteogenic activity was likely driven by the growth factors and bioactive molecules present in the CM. The study concluded that supplementing the biocement extracts with only 5% of 10X concentrated CM is sufficient to significantly influence and improve the in vitro characteristics, cell behavior, gene expression, and synthesis of cell products. It was demonstrated that, especially in the CAS supplemented with CM (CAS + CM) extract system, the improvement in osteogenic properties was due to the synergistic effect between the higher concentration of calcium ions in extracts released from the calcium sulfate hemihydrate-containing cement and the bioactive molecules supplied by the CM. Full article
(This article belongs to the Special Issue Development of Biocomposites for Bone Tissue Engineering)
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