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Advanced Biodegradable Biomaterials
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Advanced Biodegradable Biomaterials

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983).

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 4873

Special Issue Editors

Dr. Junxiu Chen

E-Mail Website
Guest Editor
School of Materials Science and Engineering, Changzhou University, Changzhou, China
Interests: biodegradable materials; surface modification; magnesium; zinc; heat treatment
Prof. Dr. Mingchun Zhao

E-Mail Website
Guest Editor
School of Materials Science and Engineering, Central South University, Changsha, China
Interests: high-strength steel; Ti alloy; Mg alloy; biomaterial; antibacterial metal; biodegradation; biocompatibility
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biodegradable biomaterials play more and more important roles in the clinic. With the development of material technologies, metal-based, polymer-based, and ceramic-based biomaterials are developing continuously. Many new biodegradable materials have been developed with prospective application potential in recent years, providing a better materials platform for the design and manufacture of medical devices. This Special Issue invites those working on research and application of biodegradable biomaterials to contribute their research achievements or reviews on new biodegradable biomaterials in order to promote people to better understand and be involved in these studies. The topics of interest include (but are not limited to):

  • Additively manufactured biodegradable biomaterials;
  • Multifunctional biomaterials;
  • New biodegradable biomaterials for application in medicine and biology;
  • Advanced production techniques for biodegradable biomaterials;
  • Mechanical properties of metallic biomaterials;
  • Antimicrobial and infection-resistant implants and biomaterials;
  • Biomaterial–tissue interfaces;
  • Mechanical properties of metallic biomaterials;
  • Coatings and surface treatments of biodegradable biomaterials;
  • Biodegradable metallic biomaterials including magnesium, zinc, iron, and their alloys;
  • New areas of application for biodegradable biomaterials;
  • Surface patterning of biodegradable biomaterials.

Dr. Junxiu Chen
Prof. Dr. Mingchun Zhao
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biodegradable biomaterials
  • antibacterial
  • anti-infection
  • biodegradable
  • surface modification
  • composite
  • biocompatibility

Published Papers (3 papers)

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Research

22 pages, 5596 KiB  
Article
Evaluation of Biocompatibility of PLA/PHB/TPS Polymer Scaffolds with Different Additives of ATBC and OLA Plasticizers
by Marianna Trebuňová, Patrícia Petroušková, Alena Findrik Balogová, Gabriela Ižaríková, Peter Horňak, Darina Bačenková, Jana Demeterová and Jozef Živčák
J. Funct. Biomater. 2023, 14(8), 412; https://doi.org/10.3390/jfb14080412 - 4 Aug 2023
Cited by 4 | Viewed by 1250
Abstract
One of the blends that is usable for 3D printing while not being toxic to cell cultures is the lactic acid (PLA)/polyhydroxybutyrate (PHB)/thermoplastic starch (TPS) blend. The addition of plasticizers can change the rate of biodegradation and the biological behavior of the material. [...] Read more.
One of the blends that is usable for 3D printing while not being toxic to cell cultures is the lactic acid (PLA)/polyhydroxybutyrate (PHB)/thermoplastic starch (TPS) blend. The addition of plasticizers can change the rate of biodegradation and the biological behavior of the material. In order to evaluate the potential of the PLA/PHB/TPS material in combination with additives (plasticizers: acetyl tributyl citrate (ATBC) and oligomeric lactic acid (OLA)), for use in the field of biomedical tissue engineering, we performed a comprehensive in vitro characterization of selected mixture materials. Three types of materials were tested: I: PLA/PHB/TPS + 25% OLA, II: PLA/PHB/TPS + 30% ATBC, and III: PLA/PHB/TPS + 30% OLA. The assessment of the biocompatibility of the materials included cytotoxicity tests, such as monitoring the viability, proliferation and morphology of cells and their deposition on the surface of the materials. The cell line 7F2 osteoblasts (Mus musculus) was used in the experiments. Based on the test results, the significant influence of plasticizers on the material was confirmed, with their specific proportions in the mixtures. PLA/PHB/TPS + 25% OLA was evaluated as the optimal material for biocompatibility with 7F2 osteoblasts. The tested biomaterials have the potential for further investigation with a possible change in the proportion of plasticizers, which can have a fundamental impact on their biological properties. Full article
(This article belongs to the Special Issue Advanced Biodegradable Biomaterials)
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15 pages, 8397 KiB  
Article
Effect of Mg Contents on the Microstructure, Mechanical Properties and Cytocompatibility of Degradable Zn-0.5Mn-xMg Alloy
by Lingbo Yang, Xing Li, Lijing Yang, Xinglong Zhu, Manli Wang, Zhenlun Song, Huinan Hannah Liu, Wensheng Sun, Ruihong Dong and Jiqiang Yue
J. Funct. Biomater. 2023, 14(4), 195; https://doi.org/10.3390/jfb14040195 - 31 Mar 2023
Cited by 2 | Viewed by 1203
Abstract
The effect of magnesium (Mg) content on the microstructure, mechanical properties, and cytocompatibility of degradable Zn-0.5Mn-xMg (x = 0.05 wt%, 0.2 wt%, 0.5 wt%) alloys was investigated. The microstructure, corrosion products, mechanical properties, and corrosion properties of the three alloys were then thoroughly [...] Read more.
The effect of magnesium (Mg) content on the microstructure, mechanical properties, and cytocompatibility of degradable Zn-0.5Mn-xMg (x = 0.05 wt%, 0.2 wt%, 0.5 wt%) alloys was investigated. The microstructure, corrosion products, mechanical properties, and corrosion properties of the three alloys were then thoroughly characterized by scanning electron microscopy (SEM), electron back-scattered diffraction (EBSD), and other methods. According to the findings, the grain size of matrix was refined by the addition of Mg, while the size and quantity of Mg2Zn11 phase was increased. The Mg content could significantly improve the ultimate tensile strength (UTS) of the alloy. Compared with the Zn-0.5Mn alloy, the UTS of Zn-0.5Mn-xMg alloy was increased significantly. Zn-0.5Mn-0.5Mg exhibited the highest UTS (369.6 MPa). The strength of the alloy was influenced by the average grain size, the solid solubility of Mg, and the quantity of Mg2Zn11 phase. The increase in the quantity and size of Mg2Zn11 phase was the main reason for the transition from ductile fracture to cleavage fracture. Moreover, Zn-0.5Mn-0.2Mg alloy showed the best cytocompatibility to L-929 cells. Full article
(This article belongs to the Special Issue Advanced Biodegradable Biomaterials)
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16 pages, 3802 KiB  
Article
Degradable Pure Magnesium Used as a Barrier Film for Oral Bone Regeneration
by Xianfeng Shan, Yu Xu, Sharafadeen Kunle Kolawole, Ling Wen, Zhenwei Qi, Weiwei Xu and Junxiu Chen
J. Funct. Biomater. 2022, 13(4), 298; https://doi.org/10.3390/jfb13040298 - 15 Dec 2022
Cited by 7 | Viewed by 1571
Abstract
The barrier membrane plays an extremely critical role in guided bone regeneration (GBR), which determines the success or failure of GBR technology. In order to obtain barrier membranes with high mechanical strength and degradability, some researchers have focused on degradable magnesium alloys. However, [...] Read more.
The barrier membrane plays an extremely critical role in guided bone regeneration (GBR), which determines the success or failure of GBR technology. In order to obtain barrier membranes with high mechanical strength and degradability, some researchers have focused on degradable magnesium alloys. However, the degradation rate of pure Mg-based materials in body fluids is rather fast, thus posing an urgent problem to be solved in oral clinics. In this study, a novel micro-arc oxidation (MAO) surface-treated pure Mg membrane was prepared. Electrochemical tests, immersion experiments and in vivo experiments were carried out to investigate its potential use as a barrier membrane. The experimental results showed that the corrosion resistance of a pure Mg membrane treated by MAO is better than that of the uncoated pure Mg. The results of cell experiments showed no obvious cytotoxicity, which suggests the enhanced differentiation of osteoblasts. At the same time, the MAO-Mg membrane showed better biological activity than the pure Ti membrane in the early stage of implantation, exhibiting relatively good bone regeneration ability. Consequently, the MAO membrane has been proven to possess good application prospects for guided bone regeneration. Full article
(This article belongs to the Special Issue Advanced Biodegradable Biomaterials)
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