Mild Cognitive Impairment and Parkinson’s Disease: Epidemiology, Risk Factors and Biomarkers
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".
Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 361
Special Issue Editors
Interests: mild cognitive impairment; dementia and Alzheimer’s disease; Parkinson’s disease; epidemiology; neuropsychology; biomarkers
Interests: Parkinson’s disease; epidemiology of neurodegenerative disease; epidemiology and management of epilepsy in low-middle income countries; neuroparasitosis
Special Issue Information
Dear Colleagues,
Cognitive impairment is an increasingly recognized non-motor feature of Parkinson’s disease (PD). It encompasses the full spectrum of cognitive impairment from subjective cognitive decline to mild cognitive impairment (MCI) and dementia in PD (PDD). Standardized criteria for PD-MCI have been established by the Movement Disorder Society, with a mean point prevalence for PD-MCI of nearly 30%. A high proportion of patients with PD-MCI progress to dementia in a relatively short period of time, and PD-MCI determines a 5-fold increased risk of conversion to PDD. PD-MCI has been associated with older age, lower education, longer disease duration, more severe motor impairment, higher levodopa equivalent dose, higher levels of neuropsychiatric symptoms, and the postural instability/gait difficulty motor phenotype. Specific neurophysiological and imaging biomarkers for PD-MCI have been proposed, and low cerebrospinal fluid levels of amyloid-β 42—a marker of comorbid Alzheimer disease (AD)—have been associated with the development of cognitive decline and dementia in PD. Genetic evidence indicates that the Apolipoprotein E4-containing genotype (the strongest susceptibility gene for sporadic AD) and other genes are associated with cognitive decline in PD. This Special Issue aims to present current advances regarding epidemiological features, modifiable and non-modifiable risk factors, biomarkers, and updated evidence for the treatment of MCI in PD.
Prof. Roberto Monastero
Prof. Alessandra Nicoletti
Guest Editors
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Keywords
- Parkinson’s disease
- Cognitive impairment
- Dementia
- Risk factors
- Biomarkers
- Epidemiology
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