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Mitral Valve Stenosis or Aortic Valve Stenosis: Progress from Diagnosis to Treatment

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 28 March 2026 | Viewed by 414

Special Issue Editor


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Guest Editor
Clinica Montevergine, GVM Care and Research, 83013 Mercogliano, Italy
Interests: echocardiography; multimodality imaging; valvular heart disease; structural heart intervention

Special Issue Information

Dear Colleagues,

Degenerative valve disease with fibrocalcific aortic and mitral valve stenosis represents an increasing issue in the context of an aging population and evolving treatment options. While surgery remains the standard treatment for mitral valve stenosis—especially in degenerative forms—transcatheter aortic valve implantation (TAVI) has become an established therapy for aortic stenosis. However, percutaneous options for degenerative mitral valve stenosis are not yet standardized and remain under-investigated. The long-standing debate between surgical and transcatheter approaches in aortic stenosis continues, and the optimal timing of intervention remains controversial, particularly in asymptomatic severe disease and symptomatic moderate disease. Moreover, the presence of concomitant valvular disease presents a particularly challenging clinical scenario. Finally, some diagnostic issues are still open, especially in estimating mitral valve area in degenerative mitral disease compared to rheumatic disease or in the context of aortic stenosis, given the recent identification of the fibrotic phenotype.

In this Special Issue, we invite the submission of original research articles and reviews focused on diagnostic strategies, timing of intervention, long-term outcomes, and novel techniques for addressing mitral and/or aortic stenosis. Contributions exploring the management of concomitant valvular disease are especially encouraged.

We look forward to receiving your work.

Dr. Francesco Melillo
Guest Editor

Manuscript Submission Information

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Keywords

  • aortic stenosis
  • mitral stenosis
  • TAVI

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Published Papers (1 paper)

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Review

19 pages, 576 KB  
Review
Aortic Valve Stenosis: Progress from Diagnosis to Treatment
by Paolo Ossola, Simone Ghidini, Elena Gualini, Francesca Daus, Francesco Politi, Claudio Ciampi, Roberto Spoladore, Francesco Musca, Alessandro Maloberti and Cristina Giannattasio
J. Clin. Med. 2026, 15(2), 659; https://doi.org/10.3390/jcm15020659 - 14 Jan 2026
Viewed by 212
Abstract
Aortic stenosis (AS) is the most prevalent valvular heart disease in Western countries and it is especially associated with older age. With its progressive course, AS leads to ventricular hypertrophy, impaired diastolic and systolic function, and symptomatic deterioration. The natural history of AS [...] Read more.
Aortic stenosis (AS) is the most prevalent valvular heart disease in Western countries and it is especially associated with older age. With its progressive course, AS leads to ventricular hypertrophy, impaired diastolic and systolic function, and symptomatic deterioration. The natural history of AS is closely linked to the extent of myocardial and extracardiac damage in association with the patients comorbidities. Diagnosis relies primarily on transthoracic echocardiography, which assesses valve morphology, quantifies stenosis severity, and evaluates cardiac remodeling. However, discordant grading is frequent, necessitating advanced imaging to clarify the severity and the mechanism of the stenosis and stratify risk. Treatment is predominantly interventional, as no medical therapy is able to stop disease progression. Surgical aortic valve replacement (SAVR) and transcatheter aortic valve replacement (TAVR) are the two treatment options. Special clinical scenarios—such as cardiogenic shock or concomitant cardiac amyloidosis—pose additional diagnostic and therapeutic challenges and require individualized, multidisciplinary management. Overall, contemporary AS care increasingly integrates multimodality imaging, refined risk stratification, and tailored interventional strategies to optimize outcomes. Full article
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