Stem Cell Therapy for Kidney Diseases
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Nephrology & Urology".
Deadline for manuscript submissions: closed (30 April 2021) | Viewed by 328
Special Issue Editor
Interests: stem cells; kidney diseases; regeneration
Special Issue Information
Dear Colleagues,
Mesenchymal stem or stromal cells (MSC) have afforded therapeutic promise for patients with kidney disease due to their broad anti-inflammatory and immunomodulatory functions. They secrete a range of anti-inflammatory proteins and enhance tissue repair by suppressing multiple pathogenic pathways while simultaneously promoting pro-regenerative pathways. However, the survival of transplanted cells at the site of tissue damage is critical for their long-term efficacy. There is growing evidence that the protective paracrine functions of MSCs are mediated by exosomes that contain cytokines/growth factors, signalling lipids and regulatory miRNAs. The delivery of viable MSCs that can provide a sustained release of beneficial secretome derivatives, and the efficiency of the cells following transplantation are critical for the therapeutic potential of MSCs in kidney disease to be realised. Moreover, the clinical application of the MSC-derived exosomes may have a superior safety profile and have been recognised as new candidates for cell-free treatment options. In this Special Issue, we encourage submissions that discuss different sources of MSCs and delivery systems that improve homing and survival following transplantation. Advances in tissue engineering approaches for a targeted or sustained delivery of stem cell secretome for the treatment of kidney disease are also encouraged.
Prof. Sharon D. RicardoGuest Editor
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Keywords
- Kidney disease
- Stem cells
- Exosomes
- Secretome
- Regeneration
- Tissue engineering
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