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Clinical Procedures for Diagnosis and Treatment of Cardiovascular Diseases

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiovascular Medicine".

Deadline for manuscript submissions: 20 November 2025 | Viewed by 459

Special Issue Editors


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Guest Editor
Interventional Cardiology, Heart and Vascular Services, Henry Ford Hospital, Detroit, MI, USA
Interests: structural heart disease; cardiogenic shock; evidence based

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Guest Editor
Interventional Cardiology, Heart and Vascular Services, Henry Ford Hospital, Detroit, MI, USA
Interests: cardiovascular; interventional cardiology; cardiology

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Guest Editor
Division of Cardiology, Department of Medicine, Creighton University School of Medicine, Omaha, NE, USA
Interests: coronary artery disease; computed tomography angiography; coronary artery calcium score

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Guest Editor
Division of Hospital Medicine, University of Kentucky, Lexington, KY, USA
Interests: coronary artery disease and related outcomes; heart failure interventions and pharmacological therapies; valvular heart disease and related outcomes

Special Issue Information

Dear Colleagues,

Cardiovascular diseases (CVDs) remain the leading cause of global mortality, accounting for nearly 18 million deaths annually. Despite advancements in medical science, the burden of CVDs continues to rise, driven by aging populations, sedentary lifestyles, and metabolic disorders. Early and accurate diagnosis, coupled with effective treatment strategies, is critical to mitigating this crisis. This Special Issue explores cutting-edge procedures in the diagnosis and management of cardiovascular diseases, emphasizing innovations that bridge the gap between research and clinical practice.

Recent years have witnessed transformative progress in diagnostic modalities, such as high-resolution imaging (e.g., cardiac MRI, CT angiography), wearable monitoring devices, and biomarker-based assays. Concurrently, minimally invasive interventions—including transcatheter aortic valve replacement (TAVR), robotic-assisted surgery, and bioresorbable stents—have revolutionized treatment paradigms, improving patient outcomes and reducing recovery times. However, challenges persist, such as optimizing risk stratification, integrating artificial intelligence (AI) into clinical workflows, and addressing disparities in access to advanced care.

This Special Issue invites contributions on novel diagnostic tools, therapeutic techniques, and interdisciplinary approaches that enhance precision medicine in cardiology. Topics include but are not limited to non-invasive imaging advancements, AI-driven diagnostics, gene therapies, personalized treatment algorithms, and preventive strategies. By synthesizing insights from clinicians, researchers, and engineers, this collection aims to foster innovation, refine guidelines, and ultimately reduce the global burden of cardiovascular disease.

Dr. Ahmad Jabri
Dr. Mohammad AlQarqaz
Dr. Qais Radaideh
Dr. Ahmad Al-Abdouh
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiovascular disease
  • diagnostic imaging
  • minimally invasive procedures
  • precision medicine
  • artificial intelligence
  • interventional cardiology
  • surgical innovations
  • patient outcomes
  • preventive cardiology

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Published Papers (1 paper)

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Review

44 pages, 1002 KB  
Review
The Heart’s Small Molecules: The Importance of MicroRNAs in Cardiovascular Health
by Mustafa Yildiz, Ugur Ozkan and Metin Budak
J. Clin. Med. 2025, 14(21), 7454; https://doi.org/10.3390/jcm14217454 - 22 Oct 2025
Viewed by 282
Abstract
This comprehensive review explores the critical roles of microRNAs (miRNAS) in cardiovascular diseases, emphasizing their regulatory functions in gene expression and their involvement in disease progression. miRNAS are small, evolutionarily conserved non-coding RNAs that regulate gene expression post-transcriptionally and play essential roles in [...] Read more.
This comprehensive review explores the critical roles of microRNAs (miRNAS) in cardiovascular diseases, emphasizing their regulatory functions in gene expression and their involvement in disease progression. miRNAS are small, evolutionarily conserved non-coding RNAs that regulate gene expression post-transcriptionally and play essential roles in various cardiac conditions, including fibrosis, cardiac remodeling, apoptosis, ischemia/reperfusion injury, hypertrophy, heart failure, arrhythmias, coronary artery disease (CAD), congenital heart diseases (CHDs), cardiomyopathies, and valvular heart disease (VHD). miRNAS are increasingly recognized as sensitive and specific biomarkers for early diagnosis, disease monitoring, and evaluation of therapeutic responses across the cardiovascular disease spectrum. Ischemia/reperfusion injury leads to significant cardiac damage through elevated oxidative stress, mitochondrial dysfunction, and apoptosis. CAD, a major contributor to global morbidity and mortality, is primarily driven by atherosclerosis and chronic inflammation. Cardiac hypertrophy is initially an adaptive response to stress but may progress to heart failure if sustained. Arrhythmias arise from electrical disturbances such as reentry, abnormal automaticity, and triggered activity. Heart failure is a complex and progressive syndrome marked by poor prognosis and increasing global prevalence. VHD involves intricate molecular alterations, including myocardial fibrosis and calcification, which contribute to disease progression and adverse outcomes. Cardiomyopathies—including hypertrophic, dilated, restrictive, and arrhythmogenic forms—are influenced by genetic mutations, systemic diseases, and disrupted molecular signaling. CHDs, the most common congenital malformations, stem from structural abnormalities in cardiac development and remain a major cause of infant morbidity and mortality. Novel therapeutic methods, such as antisense oligonucleotides, miR mimics, and exosome-based delivery mechanisms, demonstrate the translational promise of miRNAs in the realm of personalized cardiovascular medicine. However, issues such as small sample sizes, inconsistent results, interspecies differences, and delivery challenges restrict the clinical application of miRNA-based therapies. This review integrates mechanistic insights, critiques the quality of available evidence, and identifies translational shortcomings. It highlights the diagnostic, prognostic, and therapeutic potential of miRNAs in reshaping cardiovascular disease treatment. Full article
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