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Advances in Endoscopic Management of Pancreatobiliary Neoplasms

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".

Deadline for manuscript submissions: closed (15 February 2025) | Viewed by 1435

Special Issue Editors


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Guest Editor
Pancreatobiliary Endoscopy and Endosonography Division, Pancreas Translational & Clinical Research Center, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy
Interests: ERCP; EUS; therapeutic EUS; pancreatic cancer; gastric outlet obstruction; jaundice; cholecystitis

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Guest Editor
1. Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium
2. Department of Gastroenterology and Hepatology, Imelda General Hospital, Bonheiden, Belgium
Interests: ERCP; therapeutic EUS; endoscopic stenting; ablation techniques; lumen-apposing metal stents

Special Issue Information

Dear Colleagues,

The advances within pancreaticobiliary endoscopy in recent decades have been remarkable. Various pancreaticobiliary diseases (e.g., early-stage pancreaticobiliary cancers, early-stage chronic pancreatitis, etc.), which were previously difficult to diagnose, are now easily characterized, especially using EUS and EUS-guided sampling. Cholangioscopy and pancreatoscopy have further expanded diagnostic and therapeutic possibilities. On the other hand, the palliation of endoscopic symptoms has also made significant progress. Complementary to ERCP, therapeutic EUS has revolutionized the possibility of obtaining minimally invasive palliation of cancer-related symptoms. The advent of the lumen-apposing metal stent has even created new endoscopic procedures, reducing the need for more invasive surgical or percutaneous interventions. In this Special Issue, we welcome authors to submit papers on the clinical advancements within diagnostic and therapeutic pancreatobiliary endoscopy.

Dr. Giuseppe Vanella
Dr. Michiel Bronswijk
Guest Editors

Manuscript Submission Information

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Keywords

  • ERCP
  • EUS
  • therapeutic EUS
  • cholangioscopy
  • LAMS
  • gastric outlet obstruction
  • jaundice
  • cholecystitis

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Published Papers (1 paper)

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Review

19 pages, 1843 KiB  
Review
Multidisciplinary Therapeutic Approaches to Pancreatic Cancer According to the Resectability Status
by Aurelio Mauro, Carlotta Faverio, Leonardo Brizzi, Stefano Mazza, Davide Scalvini, Daniele Alfieri, Alessandro Cappellini, Fabio Chicco, Carlo Ciccioli, Claudia Delogu, Marco Bardone, Anna Gallotti, Anna Pagani, Francesca Torello Viera and Andrea Anderloni
J. Clin. Med. 2025, 14(4), 1167; https://doi.org/10.3390/jcm14041167 - 11 Feb 2025
Viewed by 1060
Abstract
Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal cancers, characterized by late diagnosis, rapid progression, and limited therapeutic options. Despite advancements, only 20% of patients are eligible for surgical resection at diagnosis, the sole curative treatment. Multidisciplinary evaluation is critical to optimize [...] Read more.
Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal cancers, characterized by late diagnosis, rapid progression, and limited therapeutic options. Despite advancements, only 20% of patients are eligible for surgical resection at diagnosis, the sole curative treatment. Multidisciplinary evaluation is critical to optimize care, stratifying patients based on resectability into resectable, borderline resectable, locally advanced, and metastatic stages. Preoperative imaging, such as computed tomography (CT) and endoscopic ultrasound (EUS), remains central for staging, for vascular assessment, and tissue acquisition. Endoscopic and systemic approaches are pivotal for addressing complications like biliary obstruction and improving outcomes. Endoscopic retrograde cholangiopancreatography (ERCP) has been considered for years the gold standard for biliary drainage, although EUS-guided drainage is increasingly utilized due to its efficacy in both resectable and unresectable disease. Systemic therapies play a key role in neoadjuvant, adjuvant, and palliative settings, with ongoing trials exploring their impact on survival and resectability chance. This review highlights the evolving multidisciplinary approaches tailored to the disease stage, focusing on biliary drainage techniques, systemic therapies, and their integration into comprehensive care pathways for PDAC. The continuous refinement of these strategies offers incremental survival benefits and underscores the importance of personalized, multidisciplinary management. Full article
(This article belongs to the Special Issue Advances in Endoscopic Management of Pancreatobiliary Neoplasms)
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