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Bariatric Surgery: Current Status and Emerging Clinical Trends

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "General Surgery".

Deadline for manuscript submissions: 25 June 2026 | Viewed by 95

Special Issue Editor


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Guest Editor
Department of Surgery, NYU Grossman Long Island School of Medicine, Mineola, NY 11501, USA
Interests: bariatric and metabolic surgery; surgical innovation; robotic techniques; obesity management; outcomes research

Special Issue Information

Dear Colleagues,

Over the past two decades, bariatric and metabolic surgery has transformed from a weight-loss procedure into a cornerstone of comprehensive metabolic disease management. Rapid advancements in minimally invasive techniques, robotic technology, and enhanced recovery pathways have improved safety and outcomes, while emerging pharmacologic therapies—particularly GLP-1 receptor agonists and dual/triple incretin agents—are redefining surgical indications and postoperative care. While these burgeoning technological and innovative approaches may be viewed as challenges, they also represent a new landscape of therapeutic interventions.

We are pleased to invite you to contribute to this Special Issue, “Bariatric Surgery: Current Status and Emerging Clinical Trends,” which will explore the intersection of innovation, evidence, and patient-centered outcomes in modern bariatric practice. This collection aims to provide an updated synthesis of global trends, novel procedures, metabolic mechanisms, and combination therapies that are shaping the future of obesity and metabolic surgery.

Aim and Scope:

This Special Issue aims to highlight cutting-edge developments in bariatric surgery, including surgical techniques, perioperative care, metabolic insights and current research, and integration with pharmacologic therapies. It aligns closely with the journal’s mission to disseminate multidisciplinary research that advances clinical outcomes and translational understanding in surgery, metabolism, and obesity management.

Submissions may include original research, reviews, or meta-analyses that address current evidence, technological innovations, or emerging paradigms in metabolic and bariatric surgery. The goal is to foster collaboration between surgeons, endocrinologists, scientists, and allied professionals to define the future direction of the field.

Suggested Themes and Article Types for Submission

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following topics:

  1. Global trends in bariatric and metabolic surgery;
  2. Integration of GLP-1 and dual/triple agonists in pre- and postoperative care;
  3. Comparative long-term outcomes of sleeve gastrectomy, gastric bypass, and novel procedures (OAGB, SADI-S, ESG);
  4. Robotic and endoluminal bariatric surgery: learning curves, ergonomics;
  5. Revisional bariatric surgery and management of weight regain;
  6. ERAS and multidisciplinary models for enhanced recovery;
  7. Simulation and artificial intelligence in bariatric surgery;
  8. Psychosocial and quality-of-life outcomes after bariatric procedures;
  9. Future directions in precision metabolic surgery and combined pharmacologic-surgical therapy.

We look forward to receiving your contributions.

Prof. Dr. Collin E. M. Brathwaite
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bariatric surgery
  • metabolic surgery
  • obesity
  • GLP-1 receptor agonists
  • robotic surgery
  • revisional surgery
  • weight regain
  • metabolic mechanisms
  • enhanced recovery
  • surgical innovation

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Published Papers (1 paper)

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Research

24 pages, 3247 KB  
Article
Analysis of Roux-en-Y Gastric Bypass and High-Fat Feeding Reveals Hepatic Transcriptome Reprogramming: Ironing out the Details
by Matthew Stevenson, Munichandra Babu Tirumalasetty, Ankita Srivastava, Qing Miao, Collin Brathwaite and Louis Ragolia
J. Clin. Med. 2026, 15(2), 479; https://doi.org/10.3390/jcm15020479 - 7 Jan 2026
Abstract
Background/Objectives: Roux-en-Y gastric bypass (RYGB) improves obesity-related metabolic disorders, yet post-operative dietary composition critically shapes outcomes. This study explored how RYGB and high-fat diet (HFD) differentially regulate hepatic transcriptional programs. Methods: We performed RNA-seq on liver tissues from diet-induced obese C57BL/6 male mice [...] Read more.
Background/Objectives: Roux-en-Y gastric bypass (RYGB) improves obesity-related metabolic disorders, yet post-operative dietary composition critically shapes outcomes. This study explored how RYGB and high-fat diet (HFD) differentially regulate hepatic transcriptional programs. Methods: We performed RNA-seq on liver tissues from diet-induced obese C57BL/6 male mice 8 weeks post-RYGB or sham surgery, maintained on chow or HFD. Differentially expressed genes (DEGs) were identified using DESeq2. Gene sets were categorized as RYGB-induced (commonly regulated by surgery across diets), Reversal (RYGB-driven counter-regulation of obesity-induced changes), and HFD-induced (commonly regulated by diet). A subset of RYGB-specific HFD-induced genes was derived by excluding HFD-induced genes from the RYGB Chow vs. RYGB HFD contrast. Pathway enrichment was conducted using STRING. Results: RYGB induced 365 DEGs, including pathways related to extracellular remodeling and reduced mitochondrial/antioxidant activity. Among these, 119 Reversal genes countered obesity-associated transcriptional patterns and accounted for ~27% of the RYGB-induced enrichment results. HFD regulated 860 DEGs, highlighting stress responses and translational repression. Lastly, a set of 426 RYGB-specific HFD-induced genes revealed persistent hepatic inflammation, coagulation, and iron dysregulation under HFD despite surgery. Conclusions: RYGB induces robust hepatic transcriptomic changes that attenuate obesity-driven dysregulation, including a coordinated reprogramming of iron-handling pathways. However, high dietary fat partially overrides these benefits, promoting inflammatory, metabolic stress, and iron-related stress. Optimizing post-operative diets and carefully managing micronutrient intake, especially iron, may enhance RYGB’s metabolic efficacy and long-term liver health. Full article
(This article belongs to the Special Issue Bariatric Surgery: Current Status and Emerging Clinical Trends)
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