Special Issue "Cardiac Fibroblasts and Fibrosis"

Special Issue Editor

Guest Editor
Prof. Michelle Tallquist

Center for Cardiovascular Research, BSB311E, 651 Ilalo St, Honolulu, HI 96813, USA
Website | E-Mail
Interests: fibroblasts; Tcf21; PDGF signaling; cardiovascular development; extracellular matrix; inflammation; epicardial cell differentiation

Special Issue Information

Dear colleagues,

The Journal of Cardiovascular Development and Disease announces a Special Issue on cardiac fibroblasts and fibrosis. Cardiac fibrosis is associated with most pathological conditions of the heart, yet few therapeutic strategies have been identified that successfully reduce fibrosis progression. While the cardiac fibroblast has long been appreciated for its contribution to extracellular matrix remodeling after heart injury and during aging, effective mechanisms for curtailing fibroblast expansion and ECM deposition are minimal. One explanation for the lack of treatment options is a relatively poor understanding of the fibroblast and the signaling mechanisms that guide its behavior. Recent studies have provided a better comprehension of cardiac fibroblast gene expression and demonstrated multiple developmental origins, but there remains a need to understand fibroblast diversity after injury with consideration of temporal and spatial distinctions. A deeper understanding of the range of signaling pathways that dictate fibroblast behaviors during homeostasis and after injury is also needed. The aim of this Special Issue is to provide a venue for studies that show an appreciation of the diversity of resident cardiac fibroblast signaling and gene expression during development, cardiac remodeling, and aging.

Prof. Michelle Tallquist
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Cardiovascular Development and Disease is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Fibroblasts
  • Fibrosis
  • Cardiac development
  • Aging
  • Extracellular matrix
  • Ischemia
  • Cardiac remodeling

Published Papers (1 paper)

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Open AccessArticle
Ischemia Reperfusion Injury Produces, and Ischemic Preconditioning Prevents, Rat Cardiac Fibroblast Differentiation: Role of KATP Channels
J. Cardiovasc. Dev. Dis. 2019, 6(2), 22; https://doi.org/10.3390/jcdd6020022
Received: 18 April 2019 / Revised: 30 May 2019 / Accepted: 31 May 2019 / Published: 4 June 2019
PDF Full-text (3481 KB) | HTML Full-text | XML Full-text
Ischemic preconditioning (IPC) and activation of ATP-sensitive potassium channels (KATP) protect cardiac myocytes from ischemia reperfusion (IR) injury. We investigated the influence of IR injury, IPC and KATP in isolated rat cardiac fibroblasts. Hearts were removed under isoflurane anesthesia. IR [...] Read more.
Ischemic preconditioning (IPC) and activation of ATP-sensitive potassium channels (KATP) protect cardiac myocytes from ischemia reperfusion (IR) injury. We investigated the influence of IR injury, IPC and KATP in isolated rat cardiac fibroblasts. Hearts were removed under isoflurane anesthesia. IR was simulated in vitro by application and removal of paraffin oil over pelleted cells. Ischemia (30, 60 and 120 min) followed by 60 min reperfusion resulted in significant differentiation of fibroblasts into myofibroblasts in culture (mean % fibroblasts ± SEM in IR vs. time control: 12 ± 1% vs. 63 ± 2%, 30 min ischemia; 15 ± 3% vs. 71 ± 4%, 60 min ischemia; 8 ± 1% vs. 55 ± 2%, 120 min ischemia). IPC (15 min ischemia, 30 min reperfusion) significantly attenuated IR-induced fibroblast differentiation (52 ± 3%) compared to 60 min IR. IPC was mimicked by opening KATP with pinacidil (50 μM; 43 ± 6%) and by selectively opening mitochondrial KATP (mKATP) with diazoxide (100 μM; 53 ± 3%). Furthermore, IPC was attenuated by inhibiting KATP with glibenclamide (10 μM; 23 ± 5%) and by selectively blocking mKATP with 5-hydroxydecanoate (100 μM; 22 ± 9%). These results suggest that (a) IR injury evoked cardiac fibroblast to myofibroblast differentiation, (b) IPC attenuated IR-induced fibroblast differentiation, (c) KATP were involved in IPC and (d) this protection involved selective activation of mKATP. Full article
(This article belongs to the Special Issue Cardiac Fibroblasts and Fibrosis)

Figure 1

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

1. Authors: Neil A. Turner and Nicola M. Blythe

Affilation: University of Leeds, UK

Title: Cardiac fibroblast p38 MAPK: A critical regulator of myocardial remodeling

2. Author: Richard J. Heads

Affilation: King’s College London, UK

3. Author: Jamila H Siamwala

Affilation: Department of Molecular Pharmacology,Physiology and Pathology, Brown University, Providence, RI

Title: Innate Immune Cells in Right Ventricular Fibrosis and Pulmonary Arterial Hypertension

4. Author: Onur Kanisicak

Affilation: University of Cincinnati, USA

5. Authors: Michael Chute, Preetinder Aujla, Zamaneh Kassiri

Affilation: University of Alberta, Canada

Title: The non-fibrillar side of fibrosis: contribution of proteoglycans and the basement membrane proteins

6. Author: Kishore Pasumarthi

Affilation: Dalhousie University, Canada

7. Author: Luis Hortells, Anne Katrine Johansen, Katherine E. Yutzey
Affilation: The Heart Institute, Cincinnati Children’s Medical Center, Cincinnati OH 45229
Title: Cardiac fibroblasts in the postnatal heart and other regenerative environments: What do we know about the architects?

8. Author: Lixia Yue
Affilation: UConn Health, USA

9. Author: Michael P. Czubryt
Affilation: Albrechtsen Research Centre, Canada
Title: Cardiac fibroblast to myofibroblast phenotype conversion – an unexploited therapeutic target
J. Cardiovasc. Dev. Dis. EISSN 2308-3425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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