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Cardiac Fibroblasts and the Extracellular Matrix in Regenerative and Nonregenerative Hearts

The Heart Institute, Cincinnati Children’s Medical Center, Cincinnati, OH 45229, USA
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J. Cardiovasc. Dev. Dis. 2019, 6(3), 29; https://doi.org/10.3390/jcdd6030029
Received: 24 July 2019 / Revised: 15 August 2019 / Accepted: 19 August 2019 / Published: 20 August 2019
(This article belongs to the Special Issue Cardiac Fibroblasts and Fibrosis)
During the postnatal period in mammals, the heart undergoes significant remodeling and cardiac cells progressively lose their embryonic characteristics. At the same time, notable changes in the extracellular matrix (ECM) composition occur with a reduction in the components considered facilitators of cellular proliferation, including fibronectin and periostin, and an increase in collagen fiber organization. Not much is known about the postnatal cardiac fibroblast which is responsible for producing the majority of the ECM, but during the days after birth, mammalian hearts can regenerate after injury with only a transient scar formation. This phenomenon has also been described in adult urodeles and teleosts, but relatively little is known about their cardiac fibroblasts or ECM composition. Here, we review the pre-existing knowledge about cardiac fibroblasts and the ECM during the postnatal period in mammals as well as in regenerative environments. View Full-Text
Keywords: cardiac fibroblast; extracellular matrix; cardiac regeneration cardiac fibroblast; extracellular matrix; cardiac regeneration
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Hortells, L.; Johansen, A.K.Z.; Yutzey, K.E. Cardiac Fibroblasts and the Extracellular Matrix in Regenerative and Nonregenerative Hearts. J. Cardiovasc. Dev. Dis. 2019, 6, 29.

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