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Inorganics
Special Issues
Advanced Porous Materials
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Advanced Porous Materials

A special issue of Inorganics (ISSN 2304-6740). This special issue belongs to the section "Inorganic Solid-State Chemistry".

Deadline for manuscript submissions: closed (31 October 2019) | Viewed by 8700

Special Issue Editor

PD Dr. Claudia Weidenthaler

E-Mail Website
Guest Editor
Department of Heterogeneous Catalysis, Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, D-45470 Mülheim an der Ruhr, Germany
Interests: heterogeneous catalysis; crystallography; in situ diffraction and spectroscopy; energy related inorganic materials; hydrogen carriers

Special Issue Information

Dear Colleagues,

The class of porous materials covers a broad range of organic and inorganic compounds among which polymer foams, ceramics, mesoporous metal oxides, alumosilicates, metal organic frameworks, or porous carbon materials are only some prominent examples. Porosity in this context describes the presence of channels or cavities either in the crystal structure or in hierarchically structured materials ranging from micropores (<2 nm) to mesopores (2–50 nm) and/or macropores (>50 nm). The varieties of chemical compositions, pore architectures, and pore sizes offer the possibility for a large number of applications. Porous materials are used for example as carriers in drug release, as catalysts, in electronic or optical devices, or for separation and fixation of environmentally hazardous compounds. This Special Issue aims to bring together the actual status of research on advanced porous materials including various aspects such as new concepts for synthesis, the use of porous materials in technical processes, or the introduction of advanced characterization techniques.

PD Dr. Claudia Weidenthaler
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Inorganics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • porous solids
  • synthesis and application
  • advanced characterization techniques
  • physical and chemical properties

Published Papers (2 papers)

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Research

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10 pages, 1821 KiB  
Article
In Vitro Evaluation of a Peptide-Mesoporous Silica Nanoparticle Drug Release System against HIV-1
by Katharina Braun, Christina M. Stürzel, Frank Kirchhoff and Mika Lindén
Inorganics 2020, 8(7), 42; https://doi.org/10.3390/inorganics8070042 - 13 Jul 2020
Cited by 5 | Viewed by 2720
Abstract
It has been shown that the optimized VIR-576 derivative of the natural HIV-1 entry inhibitor targeting the viral gp41 fusion peptide is safe and effective in infected individuals. However, high doses of this peptide were required, and stability, as well as delivery, must [...] Read more.
It has been shown that the optimized VIR-576 derivative of the natural HIV-1 entry inhibitor targeting the viral gp41 fusion peptide is safe and effective in infected individuals. However, high doses of this peptide were required, and stability, as well as delivery, must be improved for clinical application. Here, we examined the loading and release of VIR-576 into/from mesoporous silica nanoparticles (MSNs) in vitro. We found that a moderately high peptide loading of 11.5 wt % could be achieved by adsorption from PBS buffer (pH 7.2), i.e., under mild, fully peptide-compatible conditions. The release rate of peptide into the same buffer was slow and the equilibrium concentration as indicated by the adsorption isotherm could not be reached even within 50 h at the particle concentrations studied. However, a faster release was observed at lower particle concentrations, indicating that partial particle dissolution had a positive influence on peptide release. To determine the antiviral activity of VIR-576-loaded MSNs, TZM-bl indicator cells were exposed to HIV-1 and the infection rates were followed as a function of time and VIR-576 concentration. The inhibitory activity observed for VIR-576 released from the MSNs was virtually identical to that of free VIR-576 at the 48 h time point, indicating that (a) VIR-576 was released in an active form from the MSNs, and (b) the release rate in the presence of serum proteins was clearly higher than that observed under protein-free conditions. These observations are discussed based on competitive peptide/protein adsorption, as well as potential influences of serum proteins on the dissolution-reprecipitation of silica under conditions where the total silica concentration is above the saturation level for dissolved silica. Our results highlight the need for studying drug release kinetics in the presence of serum proteins, in order to allow for a better extrapolation of in vitro data to in vivo conditions. Furthermore, due to the high peptide loadings that can be achieved using MSNs as carriers, such a formulation appears promising for local release applications. For systemic administration, however, peptides with a higher potency would be needed, due to their high molar masses limiting the drug loading in terms of moles per gram carrier. Full article
(This article belongs to the Special Issue Advanced Porous Materials)
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Review

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21 pages, 4907 KiB  
Review
Mesoporous Nanocast Electrocatalysts for Oxygen Reduction and Oxygen Evolution Reactions
by Tatiana Priamushko, Rémy Guillet-Nicolas and Freddy Kleitz
Inorganics 2019, 7(8), 98; https://doi.org/10.3390/inorganics7080098 - 11 Aug 2019
Cited by 18 | Viewed by 5532
Abstract
Catalyzed oxygen evolution and oxygen reduction reactions (OER and ORR, respectively) are of particular significance in many energy conversion and storage processes. During the last decade, they emerged as potential routes to sustain the ever-growing needs of the future clean energy market. Unfortunately, [...] Read more.
Catalyzed oxygen evolution and oxygen reduction reactions (OER and ORR, respectively) are of particular significance in many energy conversion and storage processes. During the last decade, they emerged as potential routes to sustain the ever-growing needs of the future clean energy market. Unfortunately, the state-of-the-art OER and ORR electrocatalysts, which are based on noble metals, are noticeably limited by a generally high activity towards one type of reaction only, high costs and relatively low abundance. Therefore, the development of (bi)functional low-cost non-noble metal or metal-free electrocatalysts is expected to increase the practical energy density and drastically reduce the production costs. Owing to their pore properties and high surface areas, mesoporous materials show high activity towards electrochemical reactions. Among all synthesis methods available for the synthesis of non-noble mesoporous metal oxides, the hard-templating (or nanocasting) approach is one of the most attractive in terms of achieving variable morphology and porosity of the materials. In this review, we thus focus on the recent advances in the design, synthesis, characterization and efficiency of non-noble metal OER and ORR electrocatalysts obtained via the nanocasting route. Critical aspects of these materials and perspectives for future developments are also discussed. Full article
(This article belongs to the Special Issue Advanced Porous Materials)
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