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Inorganics
Special Issues
Advances in Bioorganometallic Chemistry
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Advances in Bioorganometallic Chemistry

A special issue of Inorganics (ISSN 2304-6740). This special issue belongs to the section "Bioinorganic Chemistry".

Deadline for manuscript submissions: closed (30 June 2024) | Viewed by 3290

Special Issue Editors

Prof. Dr. Yong Wang

E-Mail Website
Guest Editor
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 26003, China
Interests: bioorganometallic chemistry; ferrocene; rational drug design; medicinal organometallic chemistry
Prof. Dr. Kang-Nan Wang

E-Mail Website
Guest Editor
State Key Laboratory of Crystal Materials, Shandong University, Jinan 250100, China
Interests: sensing and imaging; photodynamic diagnostic
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Since it first appeared in the literature, bioorganometallic chemistry has become a well-established field with a worldwide following and an increasing number of related publications in major journals and textbooks. These studies led to the development of metal-based organometallic complexes with applications ranging from anticancer, antibacterial and antimalarial treatments to metalloenzymes and biosensors, bioprobes and biocatalysis for applications in biomedical science. Inorganics has a specific interest in the medicinal applications of organometallic compounds and bioconjugates. 

In this Special Issue, entitled “Advances in Bioorganometallic Chemistry”, we wish to cover the most recent advances in all aspects of bioorganometallic chemistry, e.g., medicinal and organometallic chemistry, the structure and function of metalloenzymes, organometallic probes, biosensors and organometallic bioconjugates. Both original research articles and reviews highlighting the latest advances in the field will be considered for publication. Submitted articles should contribute to the development of bioorganometallic chemistry.

Prof. Dr. Yong Wang
Prof. Dr. Kang-Nan Wang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Inorganics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioorganometallic chemistry
  • artificial enzymes
  • biocatalysis
  • metalloenzymes
  • biosensors
  • bioprobes
  • medicinal organometallic chemistry

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Published Papers (1 paper)

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Research

25 pages, 10226 KiB  
Article
Fluorescent Vitamin B12–Platinum(II) Derivatives as Potential Metallotheranostic Agents for the Treatment and Imaging of Tumors
by Rozan Mehder, Elena de la Torre-Rubio, Isabel de la Cueva-Alique, Ciaran O’Malley, Adrián Pérez-Redondo, Lourdes Gude, Eva Royo and Luca Ronconi
Inorganics 2024, 12(3), 91; https://doi.org/10.3390/inorganics12030091 - 21 Mar 2024
Cited by 2 | Viewed by 2512
Abstract
Vitamin B12 (cyanocobalamin) is an essential nutrient with very low bioavailability. Compared with normal cells, tumor cells show an increased demand for vitamin B12 to support their abnormal proliferation, which is a feature that can be exploited for the tumor-specific delivery [...] Read more.
Vitamin B12 (cyanocobalamin) is an essential nutrient with very low bioavailability. Compared with normal cells, tumor cells show an increased demand for vitamin B12 to support their abnormal proliferation, which is a feature that can be exploited for the tumor-specific delivery of therapeutic and/or diagnostic agents by functionalizing vitamin B12 with suitable metallodrugs and/or luminescent probes. In this context, we report on the design of fluorescent vitamin B12–metal conjugates of the type [FLUO–B12–{M}] in which cyanocobalamin is functionalized at the 5′-site of the ribose unit with a fluorophore (FLUO: rhodamine 6G), whereas the Co(III)–cyano moiety is N-coordinated to a metal-based anticancer scaffold ({M}: Pt(II) substrate bearing enantiopure phenylamino-oxime ligands derived from R- or S-limonene). Two novel fluorescent cyanocobalamin–platinum(II) derivatives and their corresponding non-fluorescent counterparts were successfully generated and fully characterized, including the evaluation of their lipophilicity and luminescent properties. Although they exhibit low antiproliferative activity (IC50 = 40–70 μM), both fluorescent vitamin B12–platinum(II) conjugates showed an enhanced capability to inhibit cell viability compared with the inactive metal precursors and the non-fluorescent vitamin B12–platinum(II) analogues, confirming the beneficial effect of functionalization with the rhodamine 6G scaffold not only for imaging purposes but also with the aim of improving their biological activity. Full article
(This article belongs to the Special Issue Advances in Bioorganometallic Chemistry)
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