Functional Inorganic Biomaterials for Molecular Sensing and Biomedical Applications, 2nd Edition

A special issue of Inorganics (ISSN 2304-6740). This special issue belongs to the section "Inorganic Materials".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 389

Special Issue Editor


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Guest Editor
Chemistry Department, School of Science, Ivan Hilton Science Center, New Mexico Highlands University, Las Vegas, NM, USA
Interests: inorganic materials; molecular self-assembly; drug delivery; protein folding and dynamics; modeling of functional nanomaterials
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Special Issue Information

Dear Colleagues,

It is my pleasure to invite you to contribute a full article, short communication, opinion, or review article to this Special Issue, entitled “Functional Inorganic Biomaterials for Molecular Sensing and Biomedical Applications, 2nd Edition”.

Inorganic biomaterials encompass a diverse array of materials that include metals, polymers, ceramics, and composites, and they are pivotal in chemistry, materials science, biology, medicine, and biomedical engineering. Inorganic biomaterials with tunable intrinsic properties (i.e., shape, size, surface-to-volume ratio or aspect ratio, topography, electrostatic interactions), engineerable surfaces, and functionality are sought after in molecular imaging and clinical therapy. The applications of inorganic biomaterials in biomedical imaging and beyond are quite diverse and include regenerative medicine, tumor imaging, atherosclerosis imaging, tissue engineering, drug delivery, orthopedic implants, photothermal therapy, and the design of controllable medical devices. Inorganic biomaterials, nanoparticles, and their hybrid assemblies can be applied as scaffolds to immobilize biological molecules and provide means of producing advanced materials for tailored biological applications.

Given the success of the first edition of this Special Issue, a second volume has been launched, seeking to gather original research papers and comprehensive review articles focusing on the structural characterization of inorganic biomaterials, the biophysical and biochemical properties of inorganic-based biomaterials, biocompatibility, and the applications of inorganic biomaterials, including, but not limited to, imaging and clinical therapy, such as therapeutic drug delivery, gene therapy, stem cell therapy, tissue engineering, and regenerative medicine. The invitation is open to researchers who investigate the applications of inorganic biomaterials and nanoparticles using computation and experiments. The objective of this Special Issue is to showcase recent advances in inorganic biomaterials and nanoparticles, which include all stages of the process, from design to application, as well as prospects for applications in molecular sensing, clinical diagnosis, and modern medicine.

I look forward to receiving your contributions.

Dr. Nabanita Saikia
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Inorganics is an international peer-reviewed open access monthly journal published by MDPI.

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Keywords

  • structural characterization of inorganic biomaterials
  • light-responsive inorganic biomaterials
  • biocompatibility of inorganic biomaterials
  • molecular imaging
  • therapeutic applications of inorganic biomaterials
  • inorganic biomaterial-based medical devices
  • wound healing and regenerative medicine

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Published Papers (1 paper)

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Review

33 pages, 4607 KB  
Review
A Comprehensive Physicochemical Characterization of Silver Nanoparticles as a Prerequisite for Their Successful Biomedical Applications
by Anastasia Ntolia, Theofania Chatzigiannakou, Nikolaos Michailidis and Amalia Aggeli
Inorganics 2025, 13(10), 341; https://doi.org/10.3390/inorganics13100341 - 21 Oct 2025
Viewed by 289
Abstract
Silver nanoparticles (AgNPs) are highly promising components for the development of innovative biomedical products. However, a critical issue remains the insufficient deep and quantitative understanding of their fundamental physicochemical properties. These properties essentially govern the bioactivity of silver nanoparticles and, consequently, the success [...] Read more.
Silver nanoparticles (AgNPs) are highly promising components for the development of innovative biomedical products. However, a critical issue remains the insufficient deep and quantitative understanding of their fundamental physicochemical properties. These properties essentially govern the bioactivity of silver nanoparticles and, consequently, the success of their biomedical applications. Current characterization methods do not fully capture the complex nature of AgNPs, leaving key questions unresolved, such as detailed surface properties, dynamic interactions in real biological environments, long-term changes, and the release of silver ions—all factors that influence the toxicity and performance of the nanoparticles. This gap in knowledge complicates the reproducibility of experiments, comparison of results, and proper evaluation of potential health risks associated with their use. While advanced techniques such as Atomic Force Microscopy (AFM), Inductively Coupled Plasma (ICP) spectroscopy, and X-ray Photoelectron Spectroscopy (XPS) further significantly our understanding, they still do not fully meet all the demands for understanding silver nanoparticles. Specifically, these methods face limitations in monitoring the dynamic and complex interactions of nanoparticles within real biological settings, especially physicochemical properties that are linked to toxicity and also the biological. Therefore, despite their invaluable role, these techniques represent only part of the solution for the thorough understanding and assessment of the biomedical performance of AgNPs, highlighting the need for continued research to ensure their safe and efficient biomedical utilization. Full article
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