Advanced AI and Data-Driven Learning Methods for Healthcare Applications

A special issue of Information (ISSN 2078-2489). This special issue belongs to the section "Information Applications".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 1973

Special Issue Editor


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Guest Editor
Department of Computer Science, University of Mons, 7000 Mons, Belgium
Interests: artificial intelligence; big data and large-scale multimedia management; image processing; computer-aided diagnosis; medical image analysis; cloud computing
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Special Issue Information

Dear Colleagues,

The healthcare industry is undergoing a transformation driven by the rapid advancements in artificial intelligence (AI), deep learning, machine learning, and data management. The integration of these technologies into healthcare applications holds great promise for improving medical diagnostics, treatment planning, and patient outcomes.

As healthcare data become increasingly complex and voluminous—comprising medical images (X-rays, MRIs, CT scans, etc.), patient records, genetic data, and streamline IoT data—the need for advanced image processing and data management techniques has never been more urgent. In addition, distributed learning strategies associated with privacy concerns and data heterogeneity also need to be handled. Medical systems must be able to deal with large, diverse datasets that are often multimodal, unstructured, and heterogeneous.

Efficient processing, analysis, and retrieval of medical images and associated data are critical in providing timely and accurate diagnoses, personalized medicine, and enhanced treatment monitoring. Moreover, with the rapid adoption of artificial intelligence (AI) and deep learning models, there is an increasing focus on improving the accuracy and interpretability of AI models for healthcare applications. This Special Issue seeks to explore the latest advancements in data management and image processing techniques that enable intelligent healthcare solutions, from early detection to personalized treatment.

In this context, large data management guided by decentralized learning strategies like distributed learning and federated learning could be used. Indeed, while distributed learning relies on centralized data storage and communication, federated learning emphasizes decentralized data management and privacy, making it more suitable for scenarios where data security is a priority.

This Special Issue will highlight cutting-edge research and developments aimed at overcoming the technological and computational challenges in healthcare data management and medical image processing. The goal is to showcase innovative methods, solutions, and practical applications that can enhance the effectiveness of healthcare delivery through advanced artificial intelligence, data management and image processing techniques. This Special Issue will also explore recent developments in the application of federated and or distributed learning for the diagnosis and management of medical diseases. We invite contributions that investigate new approaches, methodologies, and challenges in deploying AI-based models in clinical environments, as well as research that highlights its benefits in improving healthcare outcomes.

Potential topics for this Special Issue include, but are not limited to, the following:

  • Deep learning for medical image analysis;
  • AI-based healthcare applications (e.g., diagnostics, predictive modeling);
  • Advanced image processing techniques for medical imaging;
  • Multimodal medical image retrieval and analysis;
  • Three-dimensional medical imaging and analysis;
  • Medical image segmentation and object detection;
  • Real-time processing and decision support in healthcare systems;
  • AI for personalized medicine and treatment recommendations;
  • Medical data privacy and security management;
  • Edge computing for healthcare data processing;
  • Telemedicine and remote monitoring using image analysis;
  • Challenges in multimodal healthcare data management;
  • Distributed learning in medical imaging;
  • Federated learning for early detection and diagnosis;
  • Data privacy, security, and regulatory considerations in federated learning;
  • Collaborative model training across multiple healthcare institutions for disease diagnosis;
  • Multi-center federated learning for large-scale medical image analysis;
  • Handling data heterogeneity and imbalance in federated learning for healthcare;
  • Federated learning for personalized medicine in breast cancer and cardiac diseases;
  • Ethical implications of federated learning in healthcare;
  • Federated learning for healthcare data integration and decision support systems.

Prof. Dr. Saïd Mahmoudi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Information is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • deep learning
  • medical image analysis
  • segmentation
  • federated learning
  • distributed learning
  • multimodal learning

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Published Papers (1 paper)

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Review

34 pages, 947 KiB  
Review
Multimodal Artificial Intelligence in Medical Diagnostics
by Bassem Jandoubi and Moulay A. Akhloufi
Information 2025, 16(7), 591; https://doi.org/10.3390/info16070591 - 9 Jul 2025
Viewed by 1692
Abstract
The integration of artificial intelligence into healthcare has advanced rapidly in recent years, with multimodal approaches emerging as promising tools for improving diagnostic accuracy and clinical decision making. These approaches combine heterogeneous data sources such as medical images, electronic health records, physiological signals, [...] Read more.
The integration of artificial intelligence into healthcare has advanced rapidly in recent years, with multimodal approaches emerging as promising tools for improving diagnostic accuracy and clinical decision making. These approaches combine heterogeneous data sources such as medical images, electronic health records, physiological signals, and clinical notes to better capture the complexity of disease processes. Despite this progress, only a limited number of studies offer a unified view of multimodal AI applications in medicine. In this review, we provide a comprehensive and up-to-date analysis of machine learning and deep learning-based multimodal architectures, fusion strategies, and their performance across a range of diagnostic tasks. We begin by summarizing publicly available datasets and examining the preprocessing pipelines required for harmonizing heterogeneous medical data. We then categorize key fusion strategies used to integrate information from multiple modalities and overview representative model architectures, from hybrid designs and transformer-based vision-language models to optimization-driven and EHR-centric frameworks. Finally, we highlight the challenges present in existing works. Our analysis shows that multimodal approaches tend to outperform unimodal systems in diagnostic performance, robustness, and generalization. This review provides a unified view of the field and opens up future research directions aimed at building clinically usable, interpretable, and scalable multimodal diagnostic systems. Full article
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