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Special Issue "Zebrafish Models of Lymphocyte Development and Lymphocytic Cancers"
Deadline for manuscript submissions: closed (30 September 2019).
Interests: pediatric leukemias and lymphomas
Zebrafish (Danio rerio) have a long-standing history as models for studying vertebrate developmental processes and, more recently, in studies of the vertebrate immune system. Such work has focused on both the innate and the adaptive arms of the immune system. Lymphocytes have integral roles in both aspects of immunity. In addition, zebrafish have also been used to study immune system cancers, with the very first D. rerio cancer model being a transgenic line prone to lymphoblast malignancies, and several others since described. Tools and techniques to fluorescently label cells and to ablate or transgenically mis-express genes in specific D. rerio lineages continue to expand, making zebrafish a premier model for in vivo studies of normal and abnormal gene function in immune cells. Moreover, the recent discoveries of T regulatory cells and innate lymphoid cells in zebrafish prove once again that humans and D. rerio share similar immune cell populations, opening new avenues of research into the functional roles of these cells and the genetic programs that govern those functions. In this Special Issue, we invite contributions pertaining to these and related topics, focusing on zebrafish lymphocytes, how they develop, and the genes and mechanisms that guide their development and function. In addition, we solicit articles regarding lymphocytic cancers and the genetic events that cause malignant transformation in vertebrate lymphocytes or that drive aggressiveness and treatment resistance in lymphocyte cancers. Zebrafish are amenable to diverse experimental strategies, from genetic manipulation to real-time in vivo imaging and from high-throughput screens to gene- or cell-specific mechanistic studies. Submissions utilizing these and other approaches to study zebrafish lymphocytes in both normal and pathologic biological contexts are all of interest to this Special Issue.
Dr. J. Kimble Frazer
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Danio rerio
- B cell
- T cell
- T regulatory cell, Treg
- NK cell
- innate lymphoid cell
- T cell receptor