Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
7.8
5.6
Journals
IJMS
Special Issues
Stem Cell Therapy for Periodontal Disease
ijms-logo
Submit to IJMS Review for IJMS Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Stem Cell Therapy for Periodontal Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 6008

Special Issue Editor

Dr. Kengo Iwasaki

E-Mail Website
Guest Editor
Institute for Dental Research, Osaka Dental University, Osaka, Japan
Interests: periodontal disease; regeneration; mesenchymal stem cells

Special Issue Information

Dear Colleagues,

Periodontal disease is characterized by the chronic inflammation and reduction of tooth-supporting periodontal tissues. Periodontal regeneration using stem cells has been attracting attention for the past 20 years. While numerous animal and clinical studies have reported that stem-cell transplantation leads to the regeneration of periodontal tissues, little information is available on the mechanism of the regeneration. Additionally, some problems related to stem-cell transplantation have also come to light, such as the risk of tumorigenicity, limited cell sources, difficulty in controlling the behavior of transplanted cells, and cost of culturing transplanted cells. Therefore, periodontal regeneration using stem cells now requires ingenuity and new attempts to become a realistic treatment. These may include the search for new cell sources, the possibility of cell-free treatment, the validation of new regeneration mechanisms with stem cells, and the development of new materials for periodontal regeneration.

This Special Issue invites papers on the verification of new attempts to regenerate periodontal tissues and the clarification of regenerative mechanisms, inspired by stem-cell transplantation.

Dr. Kengo Iwasaki
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • periodontal disease
  • regeneration
  • stem cells
  • periodontal ligament
  • bone
  • scaffold materials
  • paracrine factors
  • exosome
  • angiogenesis
  • wound healing
  • exosome

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

17 pages, 104193 KiB  
Article
Cell Therapy Based on Gingiva-Derived Mesenchymal Stem Cells Seeded in a Xenogeneic Collagen Matrix for Root Coverage of RT1 Gingival Lesions: An In Vivo Experimental Study
by Nerea Sanchez, Fabio Vignoletti, Ignacio Sanz-Martin, Alejandro Coca, Javier Nuñez, Estela Maldonado, Javier Sanz-Esporrin, Irene Hernando-Pradíes, Silvia Santamaría, David Herrera, Jose A. Garcia-Sanz and Mariano Sanz
Int. J. Mol. Sci. 2022, 23(6), 3248; https://doi.org/10.3390/ijms23063248 - 17 Mar 2022
Cited by 1 | Viewed by 1981
Abstract
(1) Background: To investigate the effect of a xenogeneic collagen matrix (CMX) seeded with autologous gingiva-derived mesenchymal cells (GMSCs) when combined with a coronally advanced flap (CAF) in the treatment of localized gingival recession type 1 (RT1). (2) Methods: Dehiscence-type defects were created [...] Read more.
(1) Background: To investigate the effect of a xenogeneic collagen matrix (CMX) seeded with autologous gingiva-derived mesenchymal cells (GMSCs) when combined with a coronally advanced flap (CAF) in the treatment of localized gingival recession type 1 (RT1). (2) Methods: Dehiscence-type defects were created in seven dogs. GMSCs were isolated, transfected with a vector carrying green fluorescent protein (GFP) and expanded. Once chronified, the defects were randomly treated with (1) CAF plus the combination of CMX and GFP+ GMSCs, (2) CAF plus CMX with autologous fibroblasts, (3) CAF plus CMX and (4) CAF alone. Histological and clinical outcomes at 2- and 6-week healing periods were analyzed and compared among groups. (3) Results: Histologically, the addition of autologous cells to the CMX resulted in reduced inflammation and a variable degree of new cementum/bone formation. CMX plus GMSCs resulted in greater mean recession reduction (1.42; SD = 1.88 mm) and percentage of teeth with recession reduction of ≥2 mm (57%) when compared to the other groups, although these differences were not statistically significant. (4) Conclusions: The histometric and clinical results indicated a positive trend favouring the combination of CMX and GMSCs with the CAF when compared to the groups without cells, although these differences were not statistically significant. Full article
(This article belongs to the Special Issue Stem Cell Therapy for Periodontal Disease)
►▼ Show Figures

Figure 1

Review

Jump to: Research

14 pages, 300 KiB  
Review
Stem Cell Transplantation and Cell-Free Treatment for Periodontal Regeneration
by Kengo Iwasaki, Yihao Peng, Ryuhei Kanda, Makoto Umeda and Isao Ishikawa
Int. J. Mol. Sci. 2022, 23(3), 1011; https://doi.org/10.3390/ijms23031011 - 18 Jan 2022
Cited by 19 | Viewed by 3499
Abstract
Increasing attention has been paid to cell-based medicines. Many in vivo and in vitro studies have demonstrated the efficacy of stem cell transplantation for the regeneration of periodontal tissues over the past 20 years. Although positive evidence has accumulated regarding periodontal regeneration using [...] Read more.
Increasing attention has been paid to cell-based medicines. Many in vivo and in vitro studies have demonstrated the efficacy of stem cell transplantation for the regeneration of periodontal tissues over the past 20 years. Although positive evidence has accumulated regarding periodontal regeneration using stem cells, the exact mechanism of tissue regeneration is still largely unknown. This review outlines the practicality and emerging problems of stem cell transplantation therapy for periodontal regeneration. In addition, possible solutions to these problems and cell-free treatment are discussed. Full article
(This article belongs to the Special Issue Stem Cell Therapy for Periodontal Disease)
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop