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Gene Regulation and Neurotoxicity in Alcohol Related Pathologies

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 20 August 2026 | Viewed by 2814

Special Issue Editor


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Guest Editor
BiosearLab CIC, Royal Docks Centre for Sustainability, University of East London, London E16 2RD, UK
Interests: molecular neurobiology; alcohol addiction; drosophila models

Special Issue Information

Dear Colleagues,

I am seeking contributions for a new Special Issue on Gene Regulation and Neurotoxicity in Alcohol-Related Pathologies.

It is well established that alcohol’s impact on individuals is dependent on a range of factors, including dose, frequency, genetic background and environmental conditions; however, there are still many unanswered about its common and person-specific effects and the pathologies it causes.

The objective of this Special Issue is to collect novel works that address the neurotoxicological and genetic factors that affect alcohol-induced pathologies. Neurotoxicological research can span both pre-clinical and clinical work, and genetic work can focus on both the influence of genes on the response to alcohol or the effects of alcohol on gene function. I believe that by bringing together these two topics we can advance our understanding of alcohol-induced pathologies and offer potential strategies for treatment.   

Dr. Stefano Casalotti
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • alcohol
  • ethanol
  • gene expression
  • neurotoxicity
  • epigenetics
  • polymorphisms
  • neu-rons
  • glial cell
  • plasticity

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Published Papers (1 paper)

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Review

28 pages, 1713 KB  
Review
Neurotoxicity of Chronic Alcohol Exposure: Mechanistic Insights, Cellular Disruption, and Emerging Therapeutic Strategies
by Philip Gołaszewski, Agata Wawrzyniak, Maksymilian Kłosowicz, Aleksandra Burbelka and Krzysztof Balawender
Int. J. Mol. Sci. 2026, 27(1), 299; https://doi.org/10.3390/ijms27010299 - 27 Dec 2025
Cited by 2 | Viewed by 2525
Abstract
Chronic alcohol exposure induces complex pathophysiological changes in the central nervous system (CNS), contributing to the onset and progression of neurodegenerative disorders. This review integrates recent findings on ethanol-induced neurotoxicity, focusing on key mechanisms including oxidative stress, protein misfolding, mitochondrial dysfunction, calcium dysregulation, [...] Read more.
Chronic alcohol exposure induces complex pathophysiological changes in the central nervous system (CNS), contributing to the onset and progression of neurodegenerative disorders. This review integrates recent findings on ethanol-induced neurotoxicity, focusing on key mechanisms including oxidative stress, protein misfolding, mitochondrial dysfunction, calcium dysregulation, neuroinflammation, and epigenetic alterations. We further discuss the detrimental impact of ethanol metabolism particularly its neurotoxic intermediates such as acetaldehyde and salsolinol on neuronal integrity. Special emphasis is placed on glial cell activation, blood–brain barrier disruption, and dysregulation of survival pathways such as PI3K/Akt/mTOR. Finally, we highlight promising therapeutic strategies targeting these molecular and cellular disruptions. A comprehensive understanding of these processes is critical for the development of neuroprotective interventions aimed at mitigating alcohol-related cognitive and functional decline. Full article
(This article belongs to the Special Issue Gene Regulation and Neurotoxicity in Alcohol Related Pathologies)
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