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Synthesis, Biosynthesis and Implications of Chalcones

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 898

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Institute of Pharmaceutical Chemistry, University of Pécs, H-7624 Pécs, Hungary
Interests: chemistry biochemistry; genetics and molecular biology pharmacology; toxicology; pharmaceutics physics; astronomy medicine materials science immunology; microbiology agricultural; biological sciences engineering neuroscience environmental scie
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Special Issue Information

Dear Colleagues,

This Special Issue, titled "Synthesis, Biosynthesis and Implications of Chalcones", appears to be a fitting topic for the International Journal of Molecular Sciences (IJMS), especially in the context of biochemistry. Chalcones, with their wide-ranging biological effects, are indeed a significant area of study in biochemistry, pharmacology, and medicinal chemistry. The biological activities mentioned, such as antibacterial, antiprotozoal, and antitumor-promoting effects, are especially relevant to the journal's focus on molecular biology, drug design, and the interaction of molecules with biological systems.

From a biochemistry standpoint, the emphasis on the synthesis, structural characterization, and mechanism of action of chalcones and their derivatives could provide valuable insights into their roles in biochemical pathways and molecular interactions. This aligns well with the IJMS's scope of exploring molecular structures and their biological and industrial applications. Additionally, the mention of chalcones' interactions with nucleophilic sites and radical species links to biochemical processes, such as enzymatic reactions, oxidative stress, and antioxidant mechanisms—critical areas in biochemistry and cellular biology. Moreover, the exploration of chalcones in food, cosmetics, and other industries demonstrates their broader implications in applied biochemistry.

Therefore, this Special Issue fits well within the thematic framework of the IJMS and would be a relevant and interesting contribution to the field, especially for readers with an interest in the biochemical applications of natural and synthetic compounds.

Prof. Dr. Pal Perjesi
Guest Editor

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Keywords

  • chalcones
  • biosynthesis
  • biochemistry

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Published Papers (1 paper)

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Research

21 pages, 2019 KB  
Article
(E)-2-Benzylidenecyclanones: Part XXI—Reaction of Cyclic Chalcone Analogs with Cellular Thiols: Comparison of Reactivity of (E)-2-Arylidene-1-Indanone with -1-Tetralone and -1-Benzosuberone Analogs in Thia-Michael Reactions
by Csaba Kadlecsik, Gábor Bognár, Fatemeh Kenari, Zoltán Pintér, Júlio César de Oliveira Ribeiro, Mário G. Envall, Valter H. Carvalho-Silva, Hamilton B. Napolitano and Pál Perjési
Int. J. Mol. Sci. 2025, 26(21), 10573; https://doi.org/10.3390/ijms262110573 - 30 Oct 2025
Viewed by 529
Abstract
In vitro cytotoxicity of three (E)-3-(4′-X-benzylidene)-1-indanones (2a-c) displayed lower cytotoxicity towards murine P388 and L1210 leukemic cells as well as human Molt 4/C8 and CEM T-lymphocytes than the respective six- (3a-c) and seven-membered [...] Read more.
In vitro cytotoxicity of three (E)-3-(4′-X-benzylidene)-1-indanones (2a-c) displayed lower cytotoxicity towards murine P388 and L1210 leukemic cells as well as human Molt 4/C8 and CEM T-lymphocytes than the respective six- (3a-c) and seven-membered (4a-c) analogs. To study whether thiol reactivity—as a possible basis of their mechanism of action—correlates with the observed cytotoxicities, kinetics of the non-enzyme catalyzed reactions with reduced glutathione (GSH) and N-acetylcysteine (NAC) of 2a-c were investigated. Furthermore, it was also the aim of the work to compare the thiol reactivity of the open-chain chalcones (1) and their carbocyclic analogs (2-4) with different ring sizes (n = 5–7). The reactivity of the compounds and the stereochemical outcome of the reactions were evaluated using high-pressure liquid chromatography–mass spectrometry (HPLC-MS). Molecular modeling calculations were performed to rationalize the high initial rate and low conversion of the 2a indanone in comparison with those of the carbocyclic analog tetralone (3a) and benzosuberone (4a). Thiol reactivity and cancer cell cytotoxicity showed a dependence on both the ring size and the nature of aromatic substituents. Full article
(This article belongs to the Special Issue Synthesis, Biosynthesis and Implications of Chalcones)
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