Hydrogen Sulfide and Its Role in Human Health and Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 31 May 2026 | Viewed by 48
Special Issue Editor
Interests: liver disease; cysteine metabolism; hydrogen sulfide; biochemistry; enzymology; PLP-dependent enzymes
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
It is a pleasure to invite you to contribute to the Special Issue “Hydrogen Sulfide and Its Role in Human Health and Diseases”.
Hydrogen sulfide (H₂S) has rapidly evolved from being considered a toxic gas to a gasotransmitter, with a fundamental role in human biology. In humans, H₂S is primarily produced by three enzymes: cystathionine γ-lyase, cystathionine β-synthase, and 3-mercaptopyruvate transferase. Increasing evidence demonstrates that H₂S regulates vascular tone, mitochondrial function, cellular redox balance, neurotransmission, and immune responses. Altered H₂S signaling is now linked to major health challenges, including cardiovascular and metabolic diseases, neurodegeneration, cancer, and liver pathologies, underscoring its importance as both a physiological regulator and a potential therapeutic target. Moreover, recent studies highlight the emerging role of H₂S in host–pathogen interactions, adding a new dimension to its relevance in infection biology and immune regulation
This Special Issue advances our knowledge of H₂S biology by presenting a collection of high-quality research and comprehensive reviews exploring the multifaceted roles of H₂S in health and disease. Contributions may address molecular and cellular mechanisms, translational and preclinical models, biomarker identification, pharmacological interventions, and clinical applications of H₂S donors and modulators. By bringing together diverse perspectives, this Special Issue seeks to deepen our understanding of H₂S biology and highlight novel opportunities for intervention across a wide spectrum of human diseases.
Dr. Carolina Conter
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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Keywords
- hydrogen sulfide
- H₂S biosynthesis
- redox signaling
- mitochondrial function
- immune regulation
- host–pathogen interactions
- cardiovascular diseases
- metabolic diseases
- therapeutic applications
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