Recent Advances of Hidradenitis Suppurativa
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".
Deadline for manuscript submissions: closed (25 October 2022) | Viewed by 2962
Special Issue Editor
Special Issue Information
Dear Colleagues,
Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease of the hair follicle defined by recurrent nodules, tunnels and scarring involving the intertriginous regions. The prevalence of HS has been estimated to affect 1-4% of the general European population.
HS is associated with microbial dysbiosis and immune dysregulation. Although the role of the microbiome and potentially aberrant immune system remains unclear in the pathogenesis in HS, several studies in recent years have facilitated a better and broader understanding of HS pathogenesis. Indeed, increased levels of pro-inflammatory cytokines such as interleukin-17A and tumor necrosis factor (TNF) have been reported in serum and HS lesional skin, which may be correlated with HS disease severity. Moreover, numerous microbiome studies have independently demonstrated a consistent picture, with similarities in the microbiome characteristics as well as predicted metabolic functional pathways that may be associated with HS pathogenesis, either as part of the pathogenic process or a consequence thereof. Overall, the experimental microbiome studies point to a core HS microbiome dominated by anaerobic Gram-negative bacteria (including Prevotella spp. and Porphyromonas spp.). These species may contribute to HS pathogenesis via upregulation of antimicrobial peptides (AMPs). This may lead to the catalysis of inflammatory cascades through the recruitment of macrophages and neutrophils as well as an increase in keratinocyte proliferation. In this issue of International Journal of Molecular Sciences, we would appreciate submissions of investigations detailing biomolecular experiments in the study of HS.
Dr. Hans Christian Ring
Guest Editor
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Keywords
- hidradenitis suppurativa
- interleukins
- IL-17
- TNF-alpha
- microbiome
- antimicrobial peptides
- follicular plugging
