Molecular Mechanisms and Therapeutic Targets in Systemic Vasculitis
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 30 March 2026 | Viewed by 844
Special Issue Editor
Interests: systemic lupus erythematosus; autoimmune disease; autoinflammatory disease; Castleman’s disease; vasculitis, IgG4RD
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Systemic vasculitides represent a heterogeneous group of inflammatory disorders characterized by immune-mediated injury of blood vessels leading to tissue ischemia and organ dysfunction. Recent advances in molecular and cellular research have revealed new insights into the interplay between innate and adaptive immunity, endothelial activation, and effector pathways driving vascular inflammation and damage. Among these, complement activation has emerged as a crucial link between immune complex formation, neutrophil activation, and endothelial injury, contributing to both acute inflammation and chronic vascular remodeling.
This Special Issue aims to gather high-quality original research articles and comprehensive reviews focused on the molecular and immunopathogenic mechanisms underlying systemic vasculitis, including ANCA-associated vasculitides (GPA, MPA, and EGPA), immune complex–mediated and large-vessel vasculitis, as well as other autoinflammatory or clonal forms of vascular inflammation. Topics of interest include genetic susceptibility, cytokine and signaling networks, complement dysregulation, eosinophil-driven inflammation, endothelial dysfunction, biomarkers, and novel therapeutic targets. By integrating translational and clinical perspectives, this Special Issue aims to highlight current challenges and future directions in understanding and managing vasculitis at the molecular level.
Dr. Andrés González-García
Guest Editor
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Keywords
- vasculitis
- ANCA-associated vasculitis
- EGPA
- complement activation
- molecular immunopathogenesis
- endothelial dysfunction
- cytokine signaling
- biomarkers
- therapeutic targets
- autoimmunity
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