From Molecular Insights to Novel Therapies: Advances in Metabolic Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: 31 March 2026 | Viewed by 32
Special Issue Editor
2. Laboratory of Biochemistry and Pharmacology, Departament of Pharmacology and Physiology, Drug Research and Development Center (DRDC), Medical School, Federal University of Ceará, Rua Coronel Nunes de Melo, Fortaleza 60430-275, CE, Brazil
Interests: natural compounds; diabetes; chronic diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Metabolic diseases, including diabetes, obesity, dyslipidemia, and metabolic syndrome, represent a growing global health challenge. In 2024, worldwide expenditures related to these conditions exceeded USD 1 trillion, underscoring their social and economic impact. Despite progress, current therapies often present adverse effects, limited long-term efficacy, and low patient adherence, highlighting the urgent need for innovative strategies that integrate molecular insights with translational applications. Advances in molecular pharmacology, bioinformatics, and systems medicine have enabled the discovery of novel therapeutic candidates and improved the understanding of mechanisms underlying insulin resistance, inflammation, oxidative stress, and metabolic dysregulation. These developments emphasize the importance of combining in silico predictions, preclinical models, and clinical evaluation to accelerate the translation of discoveries into effective therapies.
This Special Issue invites original research and reviews addressing molecular pathways and therapeutic innovations in metabolic diseases. Topics include drug discovery and design, computational and experimental pharmacology, biomarkers, oxidative and inflammatory pathways, polypharmacology for comorbidities, and clinical or translational studies that bridge molecular mechanisms to patient outcomes.
Dr. Marisa Jádna Silva Frederico
Guest Editor
Manuscript Submission Information
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Keywords
- diabetes mellitus
- obesity
- metabolic syndrome
- dyslipidemia and insulin resistance
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