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Design and Synthesis of Sugar-Based Reagents and Molecules

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Macromolecules".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 1366

Special Issue Editor


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Guest Editor
Molecular Chirality Research Center, Institute of Environmental Horticulture, Chiba University, Matsudo, Chiba 271-8510, Japan
Interests: bioorganic chemistry; carbohydrates; synthesis; molecular design; cell membrane lipids; glycolipids; conformation; stereochemistry; oligosaccharide; biological toxins

Special Issue Information

Dear Colleagues,

Sugars attract all living things on Earth, including small insects and human beings, which indicates the biological significance of sugars and carbohydrates. In conjunction with the global problems of atmospheric CO2, biofuels, and infectious diseases, research areas dealing with carbohydrates and the related sugar-based reagents and molecules attract strong interest. These problems are relevant in the context of global balance with respect to the biological consumption of CO2 and water for the production of sugars, glycans, and glycerolipids. International Journal of Molecular Sciences (IJMS), as a growing international journal, has provided us with an opportunity to launch this Special Issue, as titled above. With this opportunity, we would like to collect and share different ideas, designs, and synthetic approaches from those research groups worldwide dealing with sugars, glycans, and glycoconjugates as sugar-based reagents and biomolecules. The term ‘sugar-based reagent’ involves glycoconjugates with diverse molecular structures and functions, both artificial and designed. Also included in this term are glycerol and erythritol, as small sugar alcohols, cyclodextrins as oligosaccharides, and cell membrane glycolipids. The Special Issue aims at collecting and sharing your target sugars together with details on their chemical structures, background, design, and approaches.

Prof. Dr. Yoshihiro Nishida
Guest Editor

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Keywords

  • carbohydrates
  • sugars
  • glycoconjugates
  • glycolipids
  • molecular design
  • molecular structures
  • syntheses
  • infection diseases
  • atmospheric carbon dioxide (CO2)
  • climate changes
  • glycotechnology
  • glycans
  • glycerol
  • cyclodextrins
  • photosynthesis

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Published Papers (1 paper)

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Research

16 pages, 5165 KiB  
Article
Chitosan Particles Complexed with CA5-HIF-1α Plasmids Increase Angiogenesis and Improve Wound Healing
by Louis J. Born, Sameer Bengali, Angela Ting Wei Hsu, Sanaz Nourmohammadi Abadchi, Kai-Hua Chang, Frank Lay, Aerielle Matsangos, Christopher Johnson, Steven M. Jay and John W. Harmon
Int. J. Mol. Sci. 2023, 24(18), 14095; https://doi.org/10.3390/ijms241814095 - 14 Sep 2023
Cited by 1 | Viewed by 1103
Abstract
Wound therapies involving gene delivery to the skin have significant potential due to the advantage and ease of local treatment. However, choosing the appropriate vector to enable successful gene expression while also ensuring that the treatment’s immediate material components are conducive to healing [...] Read more.
Wound therapies involving gene delivery to the skin have significant potential due to the advantage and ease of local treatment. However, choosing the appropriate vector to enable successful gene expression while also ensuring that the treatment’s immediate material components are conducive to healing itself is critical. In this study, we utilized a particulate formulation of the polymer chitosan (chitosan particles, CPs) as a non-viral vector for the delivery of a plasmid encoding human CA5-HIF-1α, a degradation resistant form of HIF-1α, to enhance wound healing. We also compared the angiogenic potential of our treatment (HIF/CPs) to that of chitosan particles containing only the plasmid backbone (bb/CPs) and the chitosan particle vector alone (CPs). Our results indicate that chitosan particles exert angiogenic effects that are enhanced with the human CA5-HIF-1α-encoded plasmid. Moreover, HIF/CPs enhanced wound healing in diabetic db/db mice (p < 0.01), and healed tissue was found to contain a significantly increased number of blood vessels compared to bb/CPs (p < 0.01), CPs (p < 0.05) and no-treatment groups (p < 0.01). Thus, this study represents a method of gene delivery to the skin that utilizes an inherently pro-wound-healing polymer as a vector for plasmid DNA that has broad application for the expression of other therapeutic genes. Full article
(This article belongs to the Special Issue Design and Synthesis of Sugar-Based Reagents and Molecules)
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