ijms-logo

Journal Browser

Journal Browser

Nanocarriers: Design, Strategies and Biomedical Applications

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 3168

Special Issue Editor

Special Issue Information

Dear Colleagues,

Nanocarriers are used as an effective medical intervention tool in the treatment and diagnosis of illnesses. The challenges that limit the effectiveness of drugs, such as low bioavailability, in vivo instability and poor adsorption, have been effectively addressed through the use of appropriate nanocarriers. Efforts to develop nanocarriers have been reflected in the trend towards marketing nanodrug-based products. Furthermore, several nanocarriers are currently in various stages of clinical trials. Around the world, nanomedicine products based on polymers, liposomes and nanocrystals are available for the treatment of diseases such as cancer, skin and eye diseases and microbial infections. This Special Issue will cover the recent progress in the development of small organic molecules, polymers, biomolecules and inorganic drug nanocarriers. The topics of this Special Issue include the preparation, design and biological assessment of nanocarriers, in addition to sensory applications, vaccine development, tissue engineering, bone repair and wound healing.

Dr. Taehwan Oh
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanocarrier
  • nanomedicine
  • drug delivery
  • theranostics
  • biocompatible
  • hybrid nanocarrier
  • clinical applications

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

15 pages, 2719 KiB  
Review
Dextran Sulfate Nanocarriers: Design, Strategies and Biomedical Applications
by Subramaniyan Ramasundaram, Gurusamy Saravanakumar, Sivasangu Sobha and Tae Hwan Oh
Int. J. Mol. Sci. 2023, 24(1), 355; https://doi.org/10.3390/ijms24010355 - 26 Dec 2022
Cited by 11 | Viewed by 2671
Abstract
Dextran sulfate (DXS) is a hydrophilic, non-toxic, biodegradable, biocompatible and safe biopolymer. These biomedically relevant characteristics make DXS a promising building block in the development of nanocarrier systems for several biomedical applications, including imaging and drug delivery. DXS polyanion can bind with metal [...] Read more.
Dextran sulfate (DXS) is a hydrophilic, non-toxic, biodegradable, biocompatible and safe biopolymer. These biomedically relevant characteristics make DXS a promising building block in the development of nanocarrier systems for several biomedical applications, including imaging and drug delivery. DXS polyanion can bind with metal oxide nanomaterials, biological receptors and therapeutic drug molecules. By taking advantage of these intriguing properties, DXS is used to functionalize or construct nanocarriers for specific applications. In particular, the diagnostic or therapeutic active agent-loaded DXS nanoparticles are prepared by simple coating, formation of polyelectrolyte complexes with other positively charged polymers or through self-assembly of amphiphilic DXS derivatives. These nanoparticles show a potential to localize the active agents at the pathological site and minimize undesired side effects. As DXS can recognize and be taken up by macrophage surface receptors, it is also used as a targeting ligand for drug delivery. Besides as a nanocarrier scaffold material, DXS has intrinsic therapeutic potential. DXS binds to thrombin, acts as an anticoagulant and exhibits an inhibitory effect against coagulation, retrovirus, scrapie virus and human immunodeficiency virus (HIV). Herein, biomedical applications involving the use of DXS as nanocarriers for drugs, biomolecules, and imaging agents have been reviewed. A special focus has been made on strategies used for loading and delivering of drugs and biomolecules meant for treating several diseases, including cancer, inflammatory diseases and ocular disease. Full article
(This article belongs to the Special Issue Nanocarriers: Design, Strategies and Biomedical Applications)
Show Figures

Figure 1

Back to TopTop